Literature DB >> 15299313

Do C-H...O hydrogen bonds contribute to the stability of nucleic acid base pairs?

G A Leonard1, K McAuley-Hecht, T Brown, W N Hunter.   

Abstract

The possible formation of inter-base C-H.O hydrogen bonds in A.T, A.U and certain non-Watson-Crick base pairs is examined. A geometrical analysis in conjunction with implications for the thermodynamic stability of the base pairs suggests that C-H.O hydrogen bonds could form in nucleic acid base pairs. They may alleviate destabilizing interactions that would arise if an unsatisfied hydrogen-bond acceptor were present and mediate secondary hydrogen-bonding effects in these base pairs.

Entities:  

Year:  1995        PMID： 15299313     DOI： 10.1107/S0907444994004713

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  13 in total

1.  Inter-strand C-H...O hydrogen bonds stabilizing four-stranded intercalated molecules: stereoelectronic effects of O4' in cytosine-rich DNA.

Authors:  I Berger; M Egli; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

2.  H-bond stability in the tRNA(Asp) anticodon hairpin: 3 ns of multiple molecular dynamics simulations.

Authors:  P Auffinger; E Westhof
Journal:  Biophys J       Date:  1996-08       Impact factor: 4.033

3.  Knowledge-based elastic potentials for docking drugs or proteins with nucleic acids.

Authors:  Wei Ge; Bohdan Schneider; Wilma K Olson
Journal:  Biophys J       Date:  2004-10-22       Impact factor: 4.033

4.  High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target.

Authors:  Alice Dawson; Lindsay B Tulloch; Keri L Barrack; William N Hunter
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2010-11-16

5.  Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity.

Authors:  Alice Dawson; Paul K Fyfe; Florian Gillet; William N Hunter
Journal:  BMC Struct Biol       Date:  2011-04-22

6.  Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery.

Authors:  Paul K Fyfe; Alice Dawson; Marie Theres Hutchison; Scott Cameron; William N Hunter
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2010-07-09

7.  Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate.

Authors:  Rachel E Morgan; Gaëlle O Batot; Jennifer M Dement; Vincenzo A Rao; Thomas C Eadsforth; William N Hunter
Journal:  BMC Struct Biol       Date:  2011-05-09

8.  Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA.

Authors:  Anke Dierckx; Peter Dinér; Afaf H El-Sagheer; Joshi Dhruval Kumar; Tom Brown; Morten Grøtli; L Marcus Wilhelmsson
Journal:  Nucleic Acids Res       Date:  2011-01-29       Impact factor: 16.971

9.  Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme.

Authors:  Patrick E F O'Rourke; Thomas C Eadsforth; Paul K Fyfe; Sharon M Shepherd; William N Hunter
Journal:  PLoS One       Date:  2011-09-15       Impact factor: 3.240

10.  Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.

Authors:  Alice Dawson; Federica Gibellini; Natasha Sienkiewicz; Lindsay B Tulloch; Paul K Fyfe; Karen McLuskey; Alan H Fairlamb; William N Hunter
Journal:  Mol Microbiol       Date:  2006-09       Impact factor: 3.501
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