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Literature DB >> 15298358

-to: Tschoepe D, Menart B, Ferber P et al. (2003) genetic variation of the platelet surface integrin GPIIb-IIIa (PIA1/A2-SNP) shows a high association with Type 2 diabetes mellitus. Diabetologia 46:984-989.

S Rieger, G Endler, C Mannhalter, K Hsieh, W Lalouschek.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2004 PMID： 15298358 DOI： 10.1007/s00125-003-1314-2

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

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7 in total

1. The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion.

Authors: A Fritsche; A Madaus; W Renn; O Tschritter; A Teigeler; M Weisser; E Maerker; F Machicao; H Häring; M Stumvoll
Journal: J Clin Endocrinol Metab Date: 2001-10 Impact factor: 5.958

2. A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.

Authors: A Fritsche; N Stefan; E Hardt; S Schützenauer; H Häring; M Stumvoll
Journal: Eur J Clin Invest Date: 2000-05 Impact factor: 4.686

3. Disruption of IRS-2 causes type 2 diabetes in mice.

Authors: D J Withers; J S Gutierrez; H Towery; D J Burks; J M Ren; S Previs; Y Zhang; D Bernal; S Pons; G I Shulman; S Bonner-Weir; M F White
Journal: Nature Date: 1998-02-26 Impact factor: 49.962

4. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Authors: N Kubota; K Tobe; Y Terauchi; K Eto; T Yamauchi; R Suzuki; Y Tsubamoto; K Komeda; R Nakano; H Miki; S Satoh; H Sekihara; S Sciacchitano; M Lesniak; S Aizawa; R Nagai; S Kimura; Y Akanuma; S I Taylor; T Kadowaki
Journal: Diabetes Date: 2000-11 Impact factor: 9.461

-to: Tschoepe D, Menart B, Ferber P et al. (2003) genetic variation of the platelet surface integrin GPIIb-IIIa (PIA1/A2-SNP) shows a high association with Type 2 diabetes mellitus. Diabetologia 46:984-989.

1. The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion.

2. A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.

3. Disruption of IRS-2 causes type 2 diabetes in mice.

4. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

5. IRS-2 pathways integrate female reproduction and energy homeostasis.

6. Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

7. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.