| Literature DB >> 15295706 |
Naomi Sugaya1, Hiroshi Kimura, Shinya Hara, Yo Hoshino, Seiji Kojima, Tsuneo Morishima, Tatsuya Tsurumi, Kiyotaka Kuzushima.
Abstract
To clarify the pathogenesis of chronic active Epstein-Barr virus (EBV) infection, EBV-specific CD8+ T cells were enumerated, by use of human leukocyte antigen (HLA)-A*2402-restricted tetramers, in 8 patients with chronic active EBV infection, 10 patients with infectious mononucleosis, and 16 EBV-seropositive healthy control subjects. In most of the patients with chronic active EBV infection, EBV-specific CD8+ T cells were not detected. Of note, latent membrane protein 2-specific CD8+ T cells were not detectable in any patients with chronic active EBV infection. In contrast, EBV-specific CD8+ T cells were detected in patients with infectious mononucleosis and in healthy control subjects. Low frequencies of EBV-specific CD8+ T cells may be one of the immunological features of chronic active EBV infection.Entities:
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Year: 2004 PMID： 15295706 DOI： 10.1086/423285
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226