Literature DB >> 1529543

Mutations in the central polypurine tract of HIV-1 result in delayed replication.

O Hungnes1, E Tjøtta, B Grinde.   

Abstract

The reverse transcription of HIV-1 generates a linear genomic DNA with a single-stranded gap. The gap is believed to be the result of plus-strand priming from a second, centrally located, polypurine tract (PPT). A mutant containing four amino-acid-neutral purine-to-pyrimidine changes within the central PPT did not replicate as fast as wild-type virus. Another mutant with the entire 15-bp PPT deleted was replication-deficient. The results indicate that plus-strand priming at the central PPT is important for viral replication, possibly by ensuring efficient DNA synthesis.

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Year:  1992        PMID： 1529543     DOI： 10.1016/0042-6822(92)91230-r

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  26 in total

Review 1.  Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription.

Authors:  Judith G Levin; Mithun Mitra; Anjali Mascarenhas; Karin Musier-Forsyth
Journal:  RNA Biol       Date:  2010-11-01       Impact factor: 4.652

2.  Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B.

Authors:  Sebastien Wurtzer; Armelle Goubard; Fabrizio Mammano; Sentob Saragosti; Denise Lecossier; Allan J Hance; François Clavel
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

3.  The fourth central polypurine tract guides the synthesis of prototype foamy virus plus-strand DNA.

Authors:  Dongxue Chen; Jing Song; Yan Sun; Zhi Li; Didi Wen; Qingmei Liu; Wanhong Liu; Xiaohua He
Journal:  Virus Genes       Date:  2017-02-09       Impact factor: 2.332

4.  Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap.

Authors:  Ana Limón; Noriko Nakajima; Richard Lu; Hina Z Ghory; Alan Engelman
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

Review 5.  HIV-1 reverse transcription.

Authors:  Wei-Shau Hu; Stephen H Hughes
Journal:  Cold Spring Harb Perspect Med       Date:  2012-10-01       Impact factor: 6.915

Review 6.  Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.

Authors:  Stuart F J Le Grice
Journal:  J Biol Chem       Date:  2012-10-05       Impact factor: 5.157

7.  Human immunodeficiency virus type 1 central DNA flap: dynamic terminal product of plus-strand displacement dna synthesis catalyzed by reverse transcriptase assisted by nucleocapsid protein.

Authors:  L Hameau; J Jeusset; S Lafosse; D Coulaud; E Delain; T Unge; T Restle; E Le Cam; G Mirambeau
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

8.  Efficient initiation and strand transfer of polypurine tract-primed plus-strand DNA prevent strand transfer of internally initiated plus-strand DNA.

Authors:  E H Bowman; V K Pathak; W S Hu
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

9.  Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free system.

Authors:  G J Klarmann; H Yu; X Chen; J P Dougherty; B D Preston
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

10.  Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.

Authors:  J K Wakefield; H Rhim; C D Morrow
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
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