Literature DB >> 15294432

Concentration estimation via curve fitting: quantification of negative inotropic agents by using a simple mathematical method in guinea pig atria.

Rudolf Gesztelyi1, Judit Zsuga, Béla Juhász, Péter Dér, Miklós Vecsernyés, A József Szentmiklósi.   

Abstract

We created a simple method based on curve fitting in order to assess the concentration of pharmacological agonists or antagonists in the microenvironment of the receptors. We tested our method in electrically driven guinea pig left atria by estimating the concentration of N6-cyclopentyladenosine (CPA; A1 adenosine receptor agonist), acetyl-beta-methylcholine (muscarinic receptor agonist) and verapamil (L-type Ca2+ channel inhibitor) added previously to the atria in known amounts. Our results validated the fitness of the model under specified conditions. In addition, our data suggest a relatively slow elimination of CPA in isolated, practically bloodless guinea pig atrial myocardium.

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Year:  2004        PMID： 15294432     DOI： 10.1016/j.bulm.2004.03.001

Source DB:  PubMed          Journal:  Bull Math Biol        ISSN： 0092-8240            Impact factor:   1.758


  5 in total

1.  The effect of adenosine deaminase inhibition on the A1 adenosinergic and M2 muscarinergic control of contractility in eu- and hyperthyroid guinea pig atria.

Authors:  Krisztian Pak; Judit Zsuga; Zita Kepes; Tamas Erdei; Balazs Varga; Bela Juhasz; Andras Jozsef Szentmiklosi; Rudolf Gesztelyi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-04-16       Impact factor: 3.000

2.  Methodical Challenges and a Possible Resolution in the Assessment of Receptor Reserve for Adenosine, an Agonist with Short Half-Life.

Authors:  Judit Zsuga; Tamas Erdei; Katalin Szabó; Nora Lampe; Csaba Papp; Akos Pinter; Andras Jozsef Szentmiklosi; Bela Juhasz; Zoltán Szilvássy; Rudolf Gesztelyi
Journal:  Molecules       Date:  2017-05-19       Impact factor: 4.411

3.  Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists.

Authors:  Adrienn Monika Szabo; Gabor Viczjan; Tamas Erdei; Ildiko Simon; Rita Kiss; Andras Jozsef Szentmiklosi; Bela Juhasz; Csaba Papp; Judit Zsuga; Akos Pinter; Zoltan Szilvassy; Rudolf Gesztelyi
Journal:  Int J Mol Sci       Date:  2019-12-12       Impact factor: 5.923

4.  FSCPX, a Chemical Widely Used as an Irreversible A₁ Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium.

Authors:  Tamas Erdei; Adrienn Monika Szabo; Nora Lampe; Katalin Szabo; Rita Kiss; Judit Zsuga; Csaba Papp; Akos Pinter; Andras Jozsef Szentmiklosi; Zoltan Szilvassy; Bela Juhasz; Rudolf Gesztelyi
Journal:  Molecules       Date:  2018-08-30       Impact factor: 4.411

5.  Special Issue: G Protein-Coupled Adenosine Receptors: Molecular Aspects and Beyond.

Authors:  Francisco Ciruela
Journal:  Int J Mol Sci       Date:  2020-03-15       Impact factor: 5.923
  5 in total

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