Literature DB >> 15294152

Gene targeting: attention to detail.

Bart Vanhaesebroeck1, Jennifer L Rohn, Michael D Waterfield.   

Abstract

When it comes to silencing genes in mice, not all approaches are equal. An example published in this issue of Cell (Patrucco et al., 2004) suggests that caution should be used when validating potential drug targets by genetic disruption.

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Year:  2004        PMID： 15294152     DOI： 10.1016/j.cell.2004.07.018

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  11 in total

1.  Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.

Authors:  Julie R McMullen; Fatemeh Amirahmadi; Elizabeth A Woodcock; Martina Schinke-Braun; Russell D Bouwman; Kimberly A Hewitt; Janelle P Mollica; Li Zhang; Yunyu Zhang; Tetsuo Shioi; Antje Buerger; Seigo Izumo; Patrick Y Jay; Garry L Jennings
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-03       Impact factor: 11.205

2.  Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.

Authors:  Christina Ehrhardt; Thorsten Wolff; Stephan Ludwig
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

3.  Efficient and fast targeted production of murine models based on ENU mutagenesis.

Authors:  M Augustin; R Sedlmeier; T Peters; U Huffstadt; E Kochmann; D Simon; M Schöniger; S Garke-Mayerthaler; J Laufs; M Mayhaus; S Franke; M Klose; A Graupner; M Kurzmann; C Zinser; A Wolf; M Voelkel; M Kellner; M Kilian; S Seelig; A Koppius; A Teubner; D Korthaus; M Nehls; S Wattler
Journal:  Mamm Genome       Date:  2005-06       Impact factor: 2.957

4.  The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine.

Authors:  Daniel L Milligan; Sieu L Tran; Ulrich Strych; Gregory M Cook; Kurt L Krause
Journal:  J Bacteriol       Date:  2007-09-07       Impact factor: 3.490

5.  Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.

Authors:  Mauro Siragusa; Rajesh Katare; Marco Meloni; Federico Damilano; Emilio Hirsch; Costanza Emanueli; Paolo Madeddu
Journal:  Circ Res       Date:  2010-01-07       Impact factor: 17.367

6.  P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse.

Authors:  Sunil Iyengar; Andrew Clear; Csaba Bödör; Lenushka Maharaj; Abigail Lee; Maria Calaminici; Janet Matthews; Sameena Iqbal; Rebecca Auer; John Gribben; Simon Joel
Journal:  Blood       Date:  2013-01-22       Impact factor: 22.113

7.  Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells.

Authors:  Emmajayne Kingham; Melanie Welham
Journal:  J Cell Sci       Date:  2009-06-09       Impact factor: 5.285

8.  Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.

Authors:  Deborah Fenner; Stella Odili; Hee-Kyung Hong; Yumiko Kobayashi; Akira Kohsaka; Sandra M Siepka; Martha H Vitaterna; Pan Chen; Bogumil Zelent; Joseph Grimsby; Joseph S Takahashi; Franz M Matschinsky; Joseph Bass
Journal:  J Biol Chem       Date:  2011-09-15       Impact factor: 5.157

9.  The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.

Authors:  Hailong Guo; Asanga Samarakoon; Bart Vanhaesebroeck; Subramaniam Malarkannan
Journal:  J Exp Med       Date:  2008-09-22       Impact factor: 14.307

10.  Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

Authors:  Leonela Amoasii; Dimitri L Bertazzi; Hélène Tronchère; Karim Hnia; Gaëtan Chicanne; Bruno Rinaldi; Belinda S Cowling; Arnaud Ferry; Bruno Klaholz; Bernard Payrastre; Jocelyn Laporte; Sylvie Friant
Journal:  PLoS Genet       Date:  2012-10-11       Impact factor: 5.917
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