Literature DB >> 1529355

Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel.

C R Solaro1, C J Lingle.   

Abstract

Most calcium-activated potassium channels couple changes in intracellular calcium to membrane excitability by conducting a current with a probability that depends directly on submembrane calcium concentration. In rat adrenal chromaffin cells, however, a large conductance, voltage- and calcium-activated potassium channel (BK) undergoes rapid inactivation, suggesting that this channel has a physiological role different than that of other BK channels. The inactivation of the BK channel, like that of the voltage-gated Shaker B potassium channel, is removed by trypsin digestion and channels are blocked by the Shaker B amino-terminal inactivating domain. Thus, this BK channel shares functional and possibly structural homologies with other inactivating voltage-gated potassium channels.

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Year:  1992        PMID： 1529355     DOI： 10.1126/science.1529355

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  51 in total

1.  Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.

Authors:  X M Xia; J P Ding; C J Lingle
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

2.  A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

Authors:  T M Weiger; M H Holmqvist; I B Levitan; F T Clark; S Sprague; W J Huang; P Ge; C Wang; D Lawson; M E Jurman; M A Glucksmann; I Silos-Santiago; P S DiStefano; R Curtis
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

3.  Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog.

Authors:  M Wallner; P Meera; L Toro
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

4.  Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.

Authors:  Ying-Wei Wang; Jiu Ping Ding; Xiao-Ming Xia; Christopher J Lingle
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

5.  Steady-state and closed-state inactivation properties of inactivating BK channels.

Authors:  Jiu Ping Ding; Christopher J Lingle
Journal:  Biophys J       Date:  2002-05       Impact factor: 4.033

Review 6.  Roles of Na+, Ca2+, and K+ channels in the generation of repetitive firing and rhythmic bursting in adrenal chromaffin cells.

Authors:  Christopher J Lingle; Pedro L Martinez-Espinosa; Laura Guarina; Emilio Carbone
Journal:  Pflugers Arch       Date:  2017-08-03       Impact factor: 3.657

7.  Proteolytic modification of swelling-activated Cl- current in LNCaP prostate cancer epithelial cells.

Authors:  Yulia V Vitko; Nelli H Pogorelaya; Natalia Prevarskaya; Roman Skryma; Yaroslav M Shuba
Journal:  J Bioenerg Biomembr       Date:  2002-08       Impact factor: 2.945

8.  Contribution of BK channels to action potential repolarisation at minimal cytosolic Ca2+ concentration in chromaffin cells.

Authors:  Ricardo S Scott; Diego Bustillo; Luis Alcides Olivos-Oré; Inmaculada Cuchillo-Ibañez; Maria Victoria Barahona; Emilio Carbone; Antonio R Artalejo
Journal:  Pflugers Arch       Date:  2011-07-14       Impact factor: 3.657

9.  Interaction of the BKCa channel gating ring with dendrotoxins.

Authors:  Zoltan Takacs; John P Imredy; Jon-Paul Bingham; Boris S Zhorov; Edward G Moczydlowski
Journal:  Channels (Austin)       Date:  2014       Impact factor: 2.581

10.  Ion selectivity and gating of small conductance Ca(2+)-activated K+ channels in cultured rat adrenal chromaffin cells.

Authors:  Y B Park
Journal:  J Physiol       Date:  1994-12-15       Impact factor: 5.182
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