Literature DB >> 15292376

Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis.

Anatole Ghazalpour1, Sudheer Doss, Xia Yang, Jason Aten, Edward M Toomey, Atila Van Nas, Susanna Wang, Thomas A Drake, Aldons J Lusis.   

Abstract

The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks.

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Year:  2004        PMID： 15292376     DOI： 10.1194/jlr.R400006-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  15 in total

1.  Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentration.

Authors:  Thomas J Rea; Christine M Brown; Charles F Sing
Journal:  Perspect Biol Med       Date:  2006       Impact factor: 1.416

Review 2.  A systems biology approach to understanding atherosclerosis.

Authors:  Stephen A Ramsey; Elizabeth S Gold; Alan Aderem
Journal:  EMBO Mol Med       Date:  2010-03       Impact factor: 12.137

Review 3.  Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.

Authors:  Peter Csermely; Tamás Korcsmáros; Huba J M Kiss; Gábor London; Ruth Nussinov
Journal:  Pharmacol Ther       Date:  2013-02-04       Impact factor: 12.310

4.  A macrophage sterol-responsive network linked to atherogenesis.

Authors:  Lev Becker; Sina A Gharib; Angela D Irwin; Ellen Wijsman; Tomas Vaisar; John F Oram; Jay W Heinecke
Journal:  Cell Metab       Date:  2010-02-03       Impact factor: 27.287

Review 5.  The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches.

Authors:  Rachel D Simmons; Sandeep Kumar; Hanjoong Jo
Journal:  Arch Biochem Biophys       Date:  2015-12-11       Impact factor: 4.013

Review 6.  Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice.

Authors:  Thomas A Drake; Eric E Schadt; Aldons J Lusis
Journal:  Mamm Genome       Date:  2006-06-12       Impact factor: 2.957

7.  Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.

Authors:  Kathryn P Burdon; Megan E Rudock; Allison B Lehtinen; Carl D Langefeld; Donald W Bowden; Thomas C Register; Yongmei Liu; Barry I Freedman; J Jeffrey Carr; Catherine C Hedrick; Stephen S Rich
Journal:  Mediators Inflamm       Date:  2010-05-31       Impact factor: 4.711

8.  Integrative predictive model of coronary artery calcification in atherosclerosis.

Authors:  Michael McGeachie; Rachel L Badovinac Ramoni; Josyf C Mychaleckyj; Karen L Furie; Jonathan M Dreyfuss; Yongmei Liu; David Herrington; Xiuqing Guo; João A Lima; Wendy Post; Jerome I Rotter; Stephen Rich; Michèle Sale; Marco F Ramoni
Journal:  Circulation       Date:  2009-12-15       Impact factor: 29.690

Review 9.  Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis.

Authors:  Rachel D Simmons; Sandeep Kumar; Salim Raid Thabet; Sanjoli Sur; Hanjoong Jo
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2016-06-24

Review 10.  Antioxidants, inflammation and cardiovascular disease.

Authors:  Harald Mangge; Kathrin Becker; Dietmar Fuchs; Johanna M Gostner
Journal:  World J Cardiol       Date:  2014-06-26
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