| Literature DB >> 15290898 |
John F Ervin1, Catherine Pannell, Mari Szymanski, Kathleen Welsh-Bohmer, Donald E Schmechel, Christine M Hulette.
Abstract
We analyzed smooth muscle actin (SMA) immunoreactivity in brain blood vessels of 10 ApoE 4,4 Alzheimer disease (AD) patients and 10 ApoE 3,3 AD patients matched for age, sex, and duration of dementia. We also examined 10 cognitively and neuropathologically normal controls matched for age and sex. Vascular SMA immunoreactivity in the arachnoid, grey matter, and white matter was quantified by image analysis. There was less SMA immunoreactivity in blood vessels of all AD patients when compared to cognitively and neuropathologically normal controls (p < 0.001). In addition, arachnoidal vessels of ApoE 4,4 AD patients had less SMA immunoreactivity than ApoE 3,3 AD patients (p < 0.05). There is decreased vascular SMA density in arachnoid, grey matter, and white matter blood vessels in patients with AD when compared to age matched, cognitively and neuropathologically normal controls. The severity of the loss of SMA within the AD group may depend on ApoE type.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15290898 DOI： 10.1093/jnen/63.7.735
Source DB: PubMed Journal: J Neuropathol Exp Neurol ISSN： 0022-3069 Impact factor: 3.685