AIMS AND METHODS: We have investigated proopiomelanocortin (POMC) and neuropeptide Y (NPY) gene expression in the arcuate nucleus of the hypothalamus comparing high alcohol preference (HAP) rats and low alcohol preference (LAP) rats under basal conditions using in situ hybridization histochemistry. RESULTS: A significantly higher expression of POMC mRNA was observed in HAP rats compared with LAP rats. In contrast, no difference in NPY mRNA expression was observed between the two rat lines. CONCLUSIONS: These data suggest that an endogenous opioid system may contribute to alcohol preference in HAP/LAP rat lines.
AIMS AND METHODS: We have investigated proopiomelanocortin (POMC) and neuropeptide Y (NPY) gene expression in the arcuate nucleus of the hypothalamus comparing high alcohol preference (HAP) rats and low alcohol preference (LAP) rats under basal conditions using in situ hybridization histochemistry. RESULTS: A significantly higher expression of POMC mRNA was observed in HAP rats compared with LAP rats. In contrast, no difference in NPY mRNA expression was observed between the two rat lines. CONCLUSIONS: These data suggest that an endogenous opioid system may contribute to alcohol preference in HAP/LAP rat lines.
Authors: Jonna M Leyrer-Jackson; Erin K Nagy; Lauren E Hood; Jason M Newbern; Cassandra D Gipson; M Foster Olive Journal: Alcohol Date: 2020-04-15 Impact factor: 2.405
Authors: José Manuel Lerma-Cabrera; Francisca Carvajal; James C Garbutt; Montserrat Navarro; Todd E Thiele Journal: Brain Res Date: 2019-12-28 Impact factor: 3.252