Literature DB >> 15288936

Single molecule force spectroscopy on ligand-DNA complexes: from molecular binding mechanisms to biosensor applications.

Robert Ros1, Rainer Eckel, Frank Bartels, Andy Sischka, Birgit Baumgarth, Sven David Wilking, Alfred Pühler, Norbert Sewald, Anke Becker, Dario Anselmetti.   

Abstract

Recent developments in single molecule force spectroscopy (SMFS) allow direct observation and measurements of forces that hold protein-DNA complexes together. Furthermore, the mechanics of double-stranded (ds) DNA molecules in the presence of small binding ligands can be detected. The results elucidate molecular binding mechanisms and open the way for ultra sensitive and powerful biosensor applications.

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Year:  2004        PMID： 15288936     DOI： 10.1016/j.jbiotec.2004.04.029

Source DB:  PubMed          Journal:  J Biotechnol        ISSN： 0168-1656            Impact factor:   3.307


  7 in total

1.  Bayesian Uncertainty Quantification for Bond Energies and Mobilities Using Path Integral Analysis.

Authors:  Joshua C Chang; Pak-Wing Fok; Tom Chou
Journal:  Biophys J       Date:  2015-09-01       Impact factor: 4.033

2.  Direct observation method of individual single-stranded DNA molecules using fluorescent replication protein A.

Authors:  Masahiko Oshige; Shohei Kawasaki; Hiroki Takano; Kouji Yamaguchi; Hirofumi Kurita; Takeshi Mizuno; Shun-ichi Matsuura; Akira Mizuno; Shinji Katsura
Journal:  J Fluoresc       Date:  2011-01-12       Impact factor: 2.217

3.  Optical response of magnetic fluorescent microspheres used for force spectroscopy in the evanescent field.

Authors:  Alex Bijamov; Fridon Shubitidze; Piercen M Oliver; Dmitri V Vezenov
Journal:  Langmuir       Date:  2010-07-20       Impact factor: 3.882

4.  Mechanisms of small molecule-DNA interactions probed by single-molecule force spectroscopy.

Authors:  Ali A Almaqwashi; Thayaparan Paramanathan; Ioulia Rouzina; Mark C Williams
Journal:  Nucleic Acids Res       Date:  2016-04-16       Impact factor: 16.971

5.  Torsional sensing of small-molecule binding using magnetic tweezers.

Authors:  Jan Lipfert; Sven Klijnhout; Nynke H Dekker
Journal:  Nucleic Acids Res       Date:  2010-07-12       Impact factor: 16.971

Review 6.  Single-particle virology.

Authors:  Bálint Kiss; Dorottya Mudra; György Török; Zsolt Mártonfalvi; Gabriella Csík; Levente Herényi; Miklós Kellermayer
Journal:  Biophys Rev       Date:  2020-09-03

Review 7.  The Role of Single-Molecule Force Spectroscopy in Unraveling Typical and Autoimmune Heparin-induced Thrombocytopenia.

Authors:  Van-Chien Bui; Thi-Huong Nguyen
Journal:  Int J Mol Sci       Date:  2018-04-02       Impact factor: 5.923
  7 in total

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