| Literature DB >> 15288432 |
Yonghong Li1, Kristina Tacey, Lisa Doil, Ryan van Luchene, Veronica Garcia, Charles Rowland, Steve Schrodi, Diane Leong, Kit Lau, Joe Catanese, John Sninsky, Petra Nowotny, Peter Holmans, John Hardy, John Powell, Simon Lovestone, Leon Thal, Michael Owen, Julie Williams, Alison Goate, Andrew Grupe.
Abstract
Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.Entities:
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Year: 2004 PMID： 15288432 DOI： 10.1016/j.neulet.2004.05.047
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046