Syncope: facts and fiction.

According to the current state-of-art on the brainstem functional anatomy and reticular formation, authors believe that nucleus tractus solitarii (NTS) is the neural structure, which meets all the conditions of the hypothetical syncope generating, reflex centre. The afferent branch of this reflex arc represents information from different visceral sources including the brain itself. The efferent branch of this reflex arc is reticular activating system (RAS). The executive mechanism of syncope is deactivation of RAS done with the active engagement of NTS through solitarioreticular pathway (SRT) and parabrachial nuclear complex (PBC). The biological purpose of syncope would be resetting of the NTS in case of an unbearable vegetative input, which is code for triggering the mechanism described. Copyright 2004 Elsevier Ltd.