AIMS: We aimed to assess potential associations between different leucocyte components and coronary heart disease (CHD) in a prospective cohort study, and to put these findings in context of other relevant prospective studies in a meta-analysis. METHODS AND RESULTS: We report data on differential leucocyte count and CHD derived from the first National Health and Nutrition Examination Survey (NHANES I) and the NHANES 1 Epidemiologic Follow-up Study (NHEFS) involving 4625 individuals followed, on average, for 18 years. The NHEFS involved 914 incident CHD cases and yielded an adjusted risk ratio of 1.09 (0.93-1.29) comparing individuals with neutrophil counts in the top third versus those in the bottom third of the population. In a meta-analysis involving the NHEFS and four other studies comprising a total of 1764 incident CHD cases, the association of CHD with neutrophil counts was somewhat stronger than those with other specific leucocyte components (combined risk ratio=1.33 [1.17-1.50]) but there was substantial heterogeneity between the separate studies (Chi2(4), p <0.001). CONCLUSIONS: Although the present synthesis provides the most comprehensive assessment so far of specific leucocyte components in CHD, additional prospective data will be needed to resolve whether neutrophil counts are much stronger predictors of CHD risk than other components.
AIMS: We aimed to assess potential associations between different leucocyte components and coronary heart disease (CHD) in a prospective cohort study, and to put these findings in context of other relevant prospective studies in a meta-analysis. METHODS AND RESULTS: We report data on differential leucocyte count and CHD derived from the first National Health and Nutrition Examination Survey (NHANES I) and the NHANES 1 Epidemiologic Follow-up Study (NHEFS) involving 4625 individuals followed, on average, for 18 years. The NHEFS involved 914 incident CHD cases and yielded an adjusted risk ratio of 1.09 (0.93-1.29) comparing individuals with neutrophil counts in the top third versus those in the bottom third of the population. In a meta-analysis involving the NHEFS and four other studies comprising a total of 1764 incident CHD cases, the association of CHD with neutrophil counts was somewhat stronger than those with other specific leucocyte components (combined risk ratio=1.33 [1.17-1.50]) but there was substantial heterogeneity between the separate studies (Chi2(4), p <0.001). CONCLUSIONS: Although the present synthesis provides the most comprehensive assessment so far of specific leucocyte components in CHD, additional prospective data will be needed to resolve whether neutrophil counts are much stronger predictors of CHD risk than other components.
Authors: Bart Lammers; Prakash G Chandak; Elma Aflaki; Gijs H M Van Puijvelde; Branislav Radovic; Reeni B Hildebrand; Illiana Meurs; Ruud Out; Johan Kuiper; Theo J C Van Berkel; Dagmar Kolb; Guenter Haemmerle; Rudolf Zechner; Sanja Levak-Frank; Miranda Van Eck; Dagmar Kratky Journal: Arterioscler Thromb Vasc Biol Date: 2010-10-28 Impact factor: 8.311
Authors: R J Widmer; M A Freund; A J Flammer; J Sexton; R Lennon; A Romani; N Mulinacci; F F Vinceri; L O Lerman; A Lerman Journal: Eur J Nutr Date: 2012-08-08 Impact factor: 5.614
Authors: Gunnar H Heine; Alberto Ortiz; Ziad A Massy; Bengt Lindholm; Andrzej Wiecek; Alberto Martínez-Castelao; Adrian Covic; David Goldsmith; Gültekin Süleymanlar; Gérard M London; Gianfranco Parati; Rosa Sicari; Carmine Zoccali; Danilo Fliser Journal: Nat Rev Nephrol Date: 2012-03-13 Impact factor: 28.314
Authors: Jing Li; Andreas J Flammer; Martin K Reriani; Yoshiki Matsuo; Rajiv Gulati; Paul A Friedman; Randal J Thomas; Nicole P Sandhu; Lilach O Lerman; Amir Lerman Journal: Circ J Date: 2012-12-06 Impact factor: 2.993