A Leland Albright1. 1. Department of Pediatric Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. Leland.Albright@chp.edu
Abstract
OBJECT: The author conducted a retrospective review of 19 cases in which he resected thalamic tumors between 1986 and 2001. METHODS: The median age of the children was 8 years. Five different routes were used to resect the tumors; two tumors were resected via two approaches. The extent of resection was evaluated by postoperative imaging. Gross-total resections were performed in six cases and resections of greater than 90% of the tumor were conducted in 10 others; 90% or more of the tumor was resected in 84% of the cases. Seven tumors were low-grade gliomas and 12 were high grade. There was one postoperative death, and two children suffered permanent morbidity. Five of seven children with low-grade tumors are alive 2 to 12 years postoperatively; three of 11 children with high-grade tumors are alive at 2, 3, and 16 years, respectively. CONCLUSIONS: Treatment of pediatric thalamic tumors must be individualized, with consideration given to the tumor's location, enhancement, and margins as well as the published data about the correlation between extent of resection and prognosis.
OBJECT: The author conducted a retrospective review of 19 cases in which he resected thalamic tumors between 1986 and 2001. METHODS: The median age of the children was 8 years. Five different routes were used to resect the tumors; two tumors were resected via two approaches. The extent of resection was evaluated by postoperative imaging. Gross-total resections were performed in six cases and resections of greater than 90% of the tumor were conducted in 10 others; 90% or more of the tumor was resected in 84% of the cases. Seven tumors were low-grade gliomas and 12 were high grade. There was one postoperative death, and two children suffered permanent morbidity. Five of seven children with low-grade tumors are alive 2 to 12 years postoperatively; three of 11 children with high-grade tumors are alive at 2, 3, and 16 years, respectively. CONCLUSIONS: Treatment of pediatric thalamic tumors must be individualized, with consideration given to the tumor's location, enhancement, and margins as well as the published data about the correlation between extent of resection and prognosis.
Authors: Kristian Aquilina; David J Daniels; Helen Spoudeas; Kim Phipps; Hoong-Wei Gan; Frederick A Boop Journal: Childs Nerv Syst Date: 2015-08-16 Impact factor: 1.475
Authors: Paul Steinbok; Chittur Viswanathan Gopalakrishnan; Alexander R Hengel; Aleksander M Vitali; Ken Poskitt; Cynthia Hawkins; James Drake; Maria Lamberti-Pasculli; Olufemi Ajani; Walter Hader; Vivek Mehta; P Daniel McNeely; Patrick J McDonald; Adrianna Ranger; Michael Vassilyadi; Jeff Atkinson; Scott Ryall; David D Eisenstat; Juliette Hukin Journal: Childs Nerv Syst Date: 2015-11-23 Impact factor: 1.475