Literature DB >> 1528724

Ca2+ and Mg-ATP activated potassium channels from rat pulmonary artery.

B E Robertson1, P R Corry, P C Nye, R Z Kozlowski.   

Abstract

We have observed a novel class of calcium-activated potassium channel which is activated by physiological levels of intracellular ATP. These KCa,ATP channels are found on smooth muscle cells isolated from the pulmonary artery. Since their activation by ATP is Mg2+ dependent and is poorly evoked by non- or slowly-hydrolyzed ATP analogues, we conclude that it involves phosphorylation. We suggest that in hypoxia a reduction of intracellular ATP may reduce KCa,ATP channel activity and thereby tend to depolarize the cells. This effect would increase Ca2+ entry through voltage-activated Ca2+ channels and contribute to vasoconstriction.

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Year:  1992        PMID： 1528724

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  12 in total

1.  Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels.

Authors:  J Daut; W Maier-Rudolph; N von Beckerath; G Mehrke; K Günther; L Goedel-Meinen
Journal:  Science       Date:  1990-03-16       Impact factor: 47.728

Review 2.  Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone.

Authors:  M T Nelson; J B Patlak; J F Worley; N B Standen
Journal:  Am J Physiol       Date:  1990-07

3.  Hypoxic contraction of isolated rat pulmonary artery.

Authors:  D M Rodman; T Yamaguchi; R F O'Brien; I F McMurtry
Journal:  J Pharmacol Exp Ther       Date:  1989-03       Impact factor: 4.030

4.  Hypoxic pulmonary vasoconstriction: role of perivascular tissue.

Authors:  T C Lloyd
Journal:  J Appl Physiol       Date:  1968-11       Impact factor: 3.531

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

6.  Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line.

Authors:  R Z Kozlowski; C N Hales; M L Ashford
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

7.  Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation.

Authors:  R M Mentzer; R Rubio; R M Berne
Journal:  Am J Physiol       Date:  1975-12

8.  Effects of hypoxia upon contractions evoked in isolated rabbit pulmonary artery by potassium and noradrenaline.

Authors:  J F Marriott; J M Marshall
Journal:  J Physiol       Date:  1990-03       Impact factor: 5.182

9.  Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel.

Authors:  S K Chung; P H Reinhart; B L Martin; D Brautigan; I B Levitan
Journal:  Science       Date:  1991-08-02       Impact factor: 47.728

10.  Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs.

Authors:  S Rounds; I F McMurtry
Journal:  Circ Res       Date:  1981-03       Impact factor: 17.367
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  7 in total

1.  Modulation of large conductance calcium-activated K+ channel by membrane-delimited protein kinase and phosphatase activities.

Authors:  M Y Lee; H W Bang; I J Lim; D Y Uhm; S D Rhee
Journal:  Pflugers Arch       Date:  1994-11       Impact factor: 3.657

2.  Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans.

Authors:  Michael J Cutler; Xiaoping Wan; Kenneth R Laurita; Roger J Hajjar; David S Rosenbaum
Journal:  Circ Arrhythm Electrophysiol       Date:  2009-12

3.  Biophysical properties of Ca(2+)- and Mg-ATP-activated K+ channels in pulmonary arterial smooth muscle cells isolated from the rat.

Authors:  S Albarwani; B E Robertson; P C Nye; R Z Kozlowski
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657

4.  Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery.

Authors:  H Zhang; T B Bolton
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

5.  NADH and NAD modulates Ca(2+)-activated K+ channels in small pulmonary arterial smooth muscle cells of the rabbit.

Authors:  S Lee; M Park; I So; Y E Earm
Journal:  Pflugers Arch       Date:  1994-06       Impact factor: 3.657

6.  K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells.

Authors:  D J Beech; H Zhang; K Nakao; T B Bolton
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

7.  Different modulation of Ca-activated K channels by the intracellular redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit.

Authors:  M K Park; S H Lee; S J Lee; W K Ho; Y E Earm
Journal:  Pflugers Arch       Date:  1995-07       Impact factor: 3.657
  7 in total

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