BACKGROUND: Knowledge about premorbid development in psychosis can shed light upon theories about aetiology and schizophrenic heterogeneity, and form a basis for early detection initiatives. AIMS: To identify and validate patterns of premorbid functioning in first-episode psychosis. METHOD: The Premorbid Adjustment Scale was used to examine 335 patients. RESULTS: Social and academic function constituted fairly independent dimensions. Cluster analysis identified groups varying both in level and course. Patients with a stable social course compared with a deteriorating one had a shorter duration of untreated psychosis, were older, had more friends and less negative symptoms. Good childhood academic function correlated with more education, more meaningful activities and better working memory. Patients with a stable academic course were older at admission. CONCLUSIONS: Patterns of premorbid development suggest both neurodevelopmental and neuroregressive pathways to illness.
BACKGROUND: Knowledge about premorbid development in psychosis can shed light upon theories about aetiology and schizophrenic heterogeneity, and form a basis for early detection initiatives. AIMS: To identify and validate patterns of premorbid functioning in first-episode psychosis. METHOD: The Premorbid Adjustment Scale was used to examine 335 patients. RESULTS: Social and academic function constituted fairly independent dimensions. Cluster analysis identified groups varying both in level and course. Patients with a stable social course compared with a deteriorating one had a shorter duration of untreated psychosis, were older, had more friends and less negative symptoms. Good childhood academic function correlated with more education, more meaningful activities and better working memory. Patients with a stable academic course were older at admission. CONCLUSIONS: Patterns of premorbid development suggest both neurodevelopmental and neuroregressive pathways to illness.
Authors: Inge Joa; Jan Olav Johannessen; Bjørn Auestad; Svein Friis; Thomas McGlashan; Ingrid Melle; Stein Opjordsmoen; Erik Simonsen; Per Vaglum; Tor K Larsen Journal: Schizophr Bull Date: 2007-09-28 Impact factor: 9.306
Authors: Melissa A Weibell; Wenche Ten Velden Hegelstad; Bjørn Auestad; Jørgen Bramness; Julie Evensen; Ulrik Haahr; Inge Joa; Jan Olav Johannessen; Tor Ketil Larsen; Ingrid Melle; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Per Vaglum; Thomas McGlashan; Patrick McGorry; Svein Friis Journal: Schizophr Bull Date: 2017-07-01 Impact factor: 9.306
Authors: Julie Evensen; Jan Ivar Røssberg; Ulrik Haahr; Wenche ten Velden Hegelstad; Inge Joa; Jan Olav Johannessen; Hans Langeveld; T K Larsen; Ingrid Melle; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Kjetil Sundet; Per Vaglum; Svein Friis; Thomas McGlashan Journal: Psychopathology Date: 2011-01-13 Impact factor: 1.944
Authors: Helen J Stain; Kolbjørn Brønnick; Wenche T V Hegelstad; Inge Joa; Jan O Johannessen; Johannes Langeveld; Lauren Mawn; Tor K Larsen Journal: Schizophr Bull Date: 2013-11-26 Impact factor: 9.306
Authors: Daniel N Allen; Gregory P Strauss; Kimberly A Barchard; Mary Vertinski; William T Carpenter; Robert W Buchanan Journal: Schizophr Res Date: 2013-03-13 Impact factor: 4.939