OBJECTIVE: C-reactive protein (CRP), an obesity-related inflammatory marker, is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. It has been reported that diet-induced weight loss lowered CRP levels. However, the effect of exercise training, another therapy that can reduce weight, on CRP is still unclear. We examined effects of exercise training with weight loss on CRP levels and conventional cardiovascular risks. METHODS AND RESULTS: A total of 227 apparently healthy women were recruited, and 199 subjects (average age 52 years) completed a 2-month weight reduction program consisting of supervised aerobic exercises. After the program, weight was reduced from 65.8 to 62.8 kg (P<0.0001), and all conventional variables were remarkably improved. Similarly, CRP levels were significantly decreased, from 0.63 (0.28 to 1.19) to 0.41 (0.18 to 0.80) mg/L (P<0.0001). However, in contrast to other variables, the changes in CRP levels were not proportionally associated with the extent of weight reduction. In the quartile analysis of % weight reduction, the largest weight reduction quartile did not show significant decreases in CRP levels, whereas moderate quartile showed remarkable CRP decreases. CONCLUSIONS: Exercise training with weight reduction disproportionately lowered CRP levels. Considering inflammatory status, there might be an optimal pace of exercise with weight loss.
OBJECTIVE:C-reactive protein (CRP), an obesity-related inflammatory marker, is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. It has been reported that diet-induced weight loss lowered CRP levels. However, the effect of exercise training, another therapy that can reduce weight, on CRP is still unclear. We examined effects of exercise training with weight loss on CRP levels and conventional cardiovascular risks. METHODS AND RESULTS: A total of 227 apparently healthy women were recruited, and 199 subjects (average age 52 years) completed a 2-month weight reduction program consisting of supervised aerobic exercises. After the program, weight was reduced from 65.8 to 62.8 kg (P<0.0001), and all conventional variables were remarkably improved. Similarly, CRP levels were significantly decreased, from 0.63 (0.28 to 1.19) to 0.41 (0.18 to 0.80) mg/L (P<0.0001). However, in contrast to other variables, the changes in CRP levels were not proportionally associated with the extent of weight reduction. In the quartile analysis of % weight reduction, the largest weight reduction quartile did not show significant decreases in CRP levels, whereas moderate quartile showed remarkable CRP decreases. CONCLUSIONS: Exercise training with weight reduction disproportionately lowered CRP levels. Considering inflammatory status, there might be an optimal pace of exercise with weight loss.
Authors: Margaret F Lippincott; Aditi Desai; Gloria Zalos; Andrea Carlow; Janet De Jesus; Arnon Blum; Kevin Smith; Maria Rodrigo; Sushmitha Patibandla; Hira Chaudhry; Alexander P Glaser; William H Schenke; Gyorgy Csako; Myron A Waclawiw; Richard O Cannon Journal: Am J Cardiol Date: 2008-07-02 Impact factor: 2.778
Authors: Theodore J Angelopoulos; Mary P Miles; Joshua Lowndes; Stephen A Sivo; Richard L Seip; Linda S Pescatello; Robert F Zoeller; Paul S Visich; Paul M Gordon; Niall M Moyna; Paul D Thompson Journal: Metabolism Date: 2008-09 Impact factor: 8.694
Authors: Angela M Thompson; Catherine R Mikus; Ruben Q Rodarte; Brandy Distefano; Elisa L Priest; Erin Sinclair; Conrad P Earnest; Steven N Blair; Timothy S Church Journal: Contemp Clin Trials Date: 2007-10-11 Impact factor: 2.226