Literature DB >> 15284058

Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes.

Nader G Abraham1, Rita Rezzani, Luigi Rodella, Adam Kruger, Derek Taller, Giovanni Li Volti, Alvin I Goodman, Attallah Kappas.   

Abstract

Heme oxygenase (HO)-1 represents a key defense mechanism against oxidative injury. Hyperglycemia produces oxidative stress and various perturbations of cell physiology. The effect of streptozotocin (STZ)-induced diabetes on aortic HO activity, heme content, the number of circulating endothelial cells, and urinary 8-epi-isoprostane PGF2alpha (8-Epi) levels in control rats and rats overexpressing or underexpressing HO-1 was measured. HO activity was decreased in hyperglycemic rats. Hyperglycemia increased urinary 8-Epi, and this increase was augmented in rats underexpressing HO-1 and diminished in rats overexpressing HO-1. The number of detached endothelial cells and O2- formation increased in diabetic rats and in hyperglycemic animals underexpressing HO-1 and decreased in diabetic animals overexpressing HO-1 compared with controls. These data demonstrate that HO-1 gene transfer in hyperglycemic rats brings about a reduction in O2- production and a decrease in endothelial cell sloughing. Upregulation of HO-1 decreases oxidant production and endothelial cell damage and shedding and may attenuate vascular complications in diabetes.

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Year:  2004        PMID： 15284058     DOI： 10.1152/ajpheart.01187.2003

Source DB:  PubMed          Journal:  Am J Physiol Heart Circ Physiol        ISSN： 0363-6135            Impact factor:   4.733


  39 in total

1.  ApoA1: mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in heme oxygenase (HO-1) and Wnt10b.

Authors:  Luca Vanella; Ming Li; DongHyun Kim; Giuseppe Malfa; Lars Bellner; Tomoko Kawakami; Nader G Abraham
Journal:  Cell Cycle       Date:  2012-02-15       Impact factor: 4.534

Review 2.  HO-1 overexpression and underexpression: Clinical implications.

Authors:  George S Drummond; Jeffrey Baum; Menachem Greenberg; David Lewis; Nader G Abraham
Journal:  Arch Biochem Biophys       Date:  2019-08-16       Impact factor: 4.013

Review 3.  Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities.

Authors:  Young-Myeong Kim; Hyun-Ock Pae; Jeong Euy Park; Yong Chul Lee; Je Moon Woo; Nam-Ho Kim; Yoon Kyung Choi; Bok-Soo Lee; So Ri Kim; Hun-Taeg Chung
Journal:  Antioxid Redox Signal       Date:  2010-10-26       Impact factor: 8.401

Review 4.  Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.

Authors:  Nader G Abraham; Joshua M Junge; George S Drummond
Journal:  Trends Pharmacol Sci       Date:  2015-10-26       Impact factor: 14.819

Review 5.  Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract.

Authors:  Vijith Vijayan; Sebastian Mueller; Eveline Baumgart-Vogt; Stephan Immenschuh
Journal:  World J Gastroenterol       Date:  2010-07-07       Impact factor: 5.742

6.  Epileptic seizures increase circulating endothelial cells in peripheral blood as early indicators of cerebral vascular damage.

Authors:  Helena Parfenova; Charles W Leffler; Dilyara Tcheranova; Shyamali Basuroy; Aliz Zimmermann
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-04-02       Impact factor: 4.733

7.  Anti-inflammatory activity of Barleria lupulina: Identification of active compounds that activate the Nrf2 cell defense pathway, organize cortical actin, reduce stress fibers, and improve cell junctions in microvascular endothelial cells.

Authors:  Donald R Senger; Mien V Hoang; Ki Hyun Kim; Chunshun Li; Shugeng Cao
Journal:  J Ethnopharmacol       Date:  2016-09-20       Impact factor: 4.360

Review 8.  The role of reactive oxygen species in apoptosis of the diabetic kidney.

Authors:  F A D T G Wagener; D Dekker; J H Berden; A Scharstuhl; J van der Vlag
Journal:  Apoptosis       Date:  2009-12       Impact factor: 4.677

9.  Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin.

Authors:  Gianmario Sambuceti; Silvia Morbelli; Luca Vanella; Claudia Kusmic; Cecilia Marini; Michela Massollo; Carla Augeri; Mirko Corselli; Chiara Ghersi; Barbara Chiavarina; Luigi F Rodella; Antonio L'Abbate; George Drummond; Nader G Abraham; Francesco Frassoni
Journal:  Stem Cells       Date:  2009-02       Impact factor: 6.277

10.  Upregulation of heme oxygenase-1 combined with increased adiponectin lowers blood pressure in diabetic spontaneously hypertensive rats through a reduction in endothelial cell dysfunction, apoptosis and oxidative stress.

Authors:  Jian Cao; George Drummond; Kazuyoshi Inoue; Komal Sodhi; Xiao Ying Li; Shinji Omura
Journal:  Int J Mol Sci       Date:  2008-12-01       Impact factor: 6.208
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