| Literature DB >> 15283456 |
Nguyen-Hai Nam1, Dong-Ho Hong, Young-Jae You, Yong Kim, Seong-Cheol Bang, Hwan-Mook Kim, Byung-Zun Ahn.
Abstract
A series of 2, 5-dihydroxychalcones and related compounds were synthesized, and their cytotoxicities against tumor cell lines and human umbilical venous endothelial cells (HUVEC) evaluated. It was found that chalcones, with electron-withdrawing substituents on an A ring, exhibited significant cytotoxicities. Among the synthesized compounds, 2'-chloro-2, 5-dihydroxychalcone (9) was most potent, with an IC50 value as low as 0.31 microg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC.Entities:
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Year: 2004 PMID： 15283456 DOI： 10.1007/BF02980153
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946