Inflammation and atherosclerosis in acute coronary syndromes.

We review the role of inflammation in coronary artery disease, particularly its conversion from a chronic to an acute illness. An overview is provided of the various biochemical reactions that are grouped under the heading of inflammation and which lead to the development and progression of atherosclerotic vascular disease and its clinical consequences, especially acute coronary syndromes. The potential role of inflammatory markers in identifying patients at risk and for primary and secondary prevention of events is explored. The impact of current pharmacologic therapies on inflammation and possible future medicines are also discussed.