Literature DB >> 15281791

Doxorubicin accumulation in individually electrophoresed organelles.

Adrian B Anderson1, Guohua Xiong, Edgar A Arriaga.   

Abstract

We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.

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Year:  2004        PMID： 15281791     DOI： 10.1021/ja0492539

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  11 in total

1.  Capillary electrophoresis monitors enhancement in subcellular reactive oxygen species production upon treatment with doxorubicin.

Authors:  Angela R Eder; Edgar A Arriaga
Journal:  Chem Res Toxicol       Date:  2006-09       Impact factor: 3.739

2.  Analysis of the bioactivity of magnetically immunoisolated peroxisomes.

Authors:  Yaohua Wang; Thane H Taylor; Edgar A Arriaga
Journal:  Anal Bioanal Chem       Date:  2011-11-08       Impact factor: 4.142

Review 3.  Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species.

Authors:  Marc Liesa; Wei Qiu; Orian S Shirihai
Journal:  Biochim Biophys Acta       Date:  2012-08-03

4.  Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function.

Authors:  Reid Hayward; David Hydock; Noah Gibson; Stephanie Greufe; Eric Bredahl; Traci Parry
Journal:  J Physiol Biochem       Date:  2012-08-14       Impact factor: 4.158

5.  Capillary Electrophoresis with Laser-Induced Fluorescent Detection of Immunolabeled Individual Autophagy Organelles Isolated from Liver Tissue.

Authors:  Katherine A Muratore; Heather M Grundhofer; Edgar A Arriaga
Journal:  Anal Chem       Date:  2016-11-09       Impact factor: 6.986

6.  Capillary electrophoretic analysis reveals subcellular binding between individual mitochondria and cytoskeleton.

Authors:  Vratislav Kostal; Edgar A Arriaga
Journal:  Anal Chem       Date:  2011-02-10       Impact factor: 6.986

7.  Quantifying Heterogeneity of Individual Organelles in Mixed Populations via Mass Cytometry.

Authors:  Heather M G Brown; Edgar A Arriaga
Journal:  Anal Chem       Date:  2018-11-05       Impact factor: 6.986

8.  Direct sampling from human liver tissue cross sections for electrophoretic analysis of doxorubicin.

Authors:  Yaohua Wang; Jennifer Hong; Erik N K Cressman; Edgar A Arriaga
Journal:  Anal Chem       Date:  2009-05-01       Impact factor: 6.986

9.  Skeletal Muscle an Active Compartment in the Sequestering and Metabolism of Doxorubicin Chemotherapy.

Authors:  Sergio Fabris; David A MacLean
Journal:  PLoS One       Date:  2015-09-24       Impact factor: 3.240

10.  Prevention of doxorubicin-induced Cardiotoxicity by pharmacological non-hypoxic myocardial preconditioning based on Docosahexaenoic Acid (DHA) and carvedilol direct antioxidant effects: study protocol for a pilot, randomized, double-blind, controlled trial (CarDHA trial).

Authors:  Rodrigo Carrasco; María Cristina Ramirez; Kjersti Nes; Andrés Schuster; Rubén Aguayo; Marcelo Morales; Cristobal Ramos; Daniel Hasson; Camilo G Sotomayor; Pablo Henriquez; Ignacio Cortés; Marcia Erazo; Claudio Salas; Juan G Gormaz
Journal:  Trials       Date:  2020-02-04       Impact factor: 2.279
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