| Literature DB >> 15281362 |
Mara R P de Oliveira1, Thatyana R Alves, Angelo C Pinto, Helena de S Pereira, Luiz R Leão-Ferreira, Nissin Moussatché, Izabel Christina P P de Frugulhetti, Vitor F Ferreira, Maria Cecíla B V de Souza.
Abstract
Several new pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-g) and their corresponding heterocycle moieties (3a-g) were synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). The derivatives 3c and 3d showed modest inhibitory activity against vaccinia virus reaching 70% at a concentration of 100 microM. All heterocyclic compounds (3a-f) showed a modest inhibition against HSV-1, reaching the maximal inhibitory effect around 20-30%. The antiviral effects of most of the pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-f) on VV and HSV were not impressive.Entities:
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Year: 2004 PMID： 15281362 DOI： 10.1081/NCN-120038009
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381