Literature DB >> 15280945

The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones.

Karl-Heinz Altmann1.   

Abstract

Based on epothilones as powerful natural product leads several promising new anticancer agents have emerged through concerted efforts in chemistry and biology.

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Year:  2004        PMID： 15280945     DOI： 10.1039/b405839a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  10 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

Review 2.  Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives.

Authors:  Karl-Heinz Altmann; Fabienne Z Gaugaz; Raphael Schiess
Journal:  Mol Divers       Date:  2011-01-01       Impact factor: 2.943

3.  Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions.

Authors:  Gary E Keck; Robert L Giles; Victor J Cee; Carrie A Wager; Tao Yu; Matthew B Kraft
Journal:  J Org Chem       Date:  2008-12-19       Impact factor: 4.354

4.  Design, synthesis and biological evaluation of bridged epothilone D analogues.

Authors:  Qiao-Hong Chen; Thota Ganesh; Peggy Brodie; Carla Slebodnick; Yi Jiang; Abhijit Banerjee; Susan Bane; James P Snyder; David G I Kingston
Journal:  Org Biomol Chem       Date:  2008-11-06       Impact factor: 3.876

5.  A Highly Stereoselective, Efficient, and Scalable Synthesis of the C(1)-C(9) Fragment of the Epothilones.

Authors:  Corinne N Foley; James L Leighton
Journal:  Org Lett       Date:  2015-11-12       Impact factor: 6.005

6.  De(side chain) model of epothilone: bioconformer interconversions DFT study.

Authors:  Danuta Rusinska-Roszak; Marek Lozynski
Journal:  J Mol Model       Date:  2009-01-20       Impact factor: 1.810

7.  Synthesis of isotopically labeled epothilones.

Authors:  Thota Ganesh; Peggy J Brodie; Abhijit Banerjee; Susan Bane; David G I Kingston
Journal:  J Labelled Comp Radiopharm       Date:  2013-12-05       Impact factor: 1.921

8.  From nature to the laboratory and into the clinic.

Authors:  K C Nicolaou; Jason S Chen; Stephen M Dalby
Journal:  Bioorg Med Chem       Date:  2008-11-06       Impact factor: 3.641

9.  A natural love of natural products.

Authors:  David G I Kingston
Journal:  J Org Chem       Date:  2008-05-07       Impact factor: 4.354

Review 10.  Design and Synthesis of Simplified Polyketide Analogs: New Modalities beyond the Rule of 5.

Authors:  Dirk Menche
Journal:  ChemMedChem       Date:  2021-05-05       Impact factor: 3.466
  10 in total

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