OBJECTIVES/HYPOTHESIS: To determine the incidence of measurable audiometric changes in the contralateral ear and clinical bilateral Menière's disease in individuals with longstanding established unilateral Menière's disease. STUDY DESIGN: Analysis of data in an ongoing prospective study. METHODS: One hundred and one patients who were treated with intratympanic gentamicin installation for disabling unilateral Menière's disease were followed up for a minimum of 2 years. The mean follow-up time between the initial diagnosis to the last audiogram conducted was 12 +/- 7 (range 2-45) years, and the mean follow-up between the first and last audiograms conducted in our clinic was 5 +/- 3 (range 2-15) years. The incidence of Menière's disease (clinical diagnosis) as compared with audiometric changes in the contralateral ear was analyzed. RESULTS: Compared with several published reports, the development of bilateral Menière's disease in our series within the described observation period was much lower (5%). The incidence of contralateral isolated hearing loss in the low frequencies was 16% (average threshold of .25 and .5 kHz of 25 dB or more). The time interval between the initial diagnosis and the onset of contralateral findings ranged from 0 to 26 years. CONCLUSION: In our experience, individuals with disabling longstanding unilateral disease are not likely to develop bilateral disease. However, a small but significant percentage of patients have audiometric changes in the low frequencies of the contralateral ear (.25, .5 kHz).
OBJECTIVES/HYPOTHESIS: To determine the incidence of measurable audiometric changes in the contralateral ear and clinical bilateral Menière's disease in individuals with longstanding established unilateral Menière's disease. STUDY DESIGN: Analysis of data in an ongoing prospective study. METHODS: One hundred and one patients who were treated with intratympanic gentamicin installation for disabling unilateral Menière's disease were followed up for a minimum of 2 years. The mean follow-up time between the initial diagnosis to the last audiogram conducted was 12 +/- 7 (range 2-45) years, and the mean follow-up between the first and last audiograms conducted in our clinic was 5 +/- 3 (range 2-15) years. The incidence of Menière's disease (clinical diagnosis) as compared with audiometric changes in the contralateral ear was analyzed. RESULTS: Compared with several published reports, the development of bilateral Menière's disease in our series within the described observation period was much lower (5%). The incidence of contralateral isolated hearing loss in the low frequencies was 16% (average threshold of .25 and .5 kHz of 25 dB or more). The time interval between the initial diagnosis and the onset of contralateral findings ranged from 0 to 26 years. CONCLUSION: In our experience, individuals with disabling longstanding unilateral disease are not likely to develop bilateral disease. However, a small but significant percentage of patients have audiometric changes in the low frequencies of the contralateral ear (.25, .5 kHz).
Authors: Ming-Yee Lin; Ferdinand C A Timmer; Brad S Oriel; Guangwei Zhou; John J Guinan; Sharon G Kujawa; Barbara S Herrmann; Saumil N Merchant; Steven D Rauch Journal: Laryngoscope Date: 2006-06 Impact factor: 3.325
Authors: S Arndt; T Wesarg; Y Stelzig; R Jacob; A Illg; A Lesinski-Schiedat; M C Ketterer; A Aschendorff; I Speck Journal: HNO Date: 2020-01 Impact factor: 1.284
Authors: Arnaud Attyé; G Dumas; I Troprès; M Roustit; A Karkas; E Banciu; J Pietras; L Lamalle; S Schmerber; A Krainik Journal: Eur Radiol Date: 2015-03-28 Impact factor: 5.315