Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 p53 mutants: the achilles' heel of human cancers?

Literature DB >> 15280671

p53 mutants: the achilles' heel of human cancers?

Abstract

Recent scientific discoveries have thrust mutants of the tumor suppressor protein p53 into the forefront of the war on cancer, and hold out eventual hope for a small molecule drug that will be useful in treating human cancers with mutant p53 protein.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15280671

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

Keyword Cloud
Cited

9 in total

1. Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.

Authors: Samuel A Danziger; Jue Zeng; Ying Wang; Rainer K Brachmann; Richard H Lathrop
Journal: Bioinformatics Date: 2007-07-01 Impact factor: 6.937

2. The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.

Authors: Siddharth Singh; Manoj Kumar; Sanjeev Kumar; Shrinka Sen; Pawan Upadhyay; Sayan Bhattacharjee; Naveen M; Vivek Singh Tomar; Siddhartha Roy; Amit Dutt; Tapas K Kundu
Journal: J Biol Chem Date: 2019-07-31 Impact factor: 5.157

3. Study on the association of p53 codon 72 polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu Province in China.

Authors: Zhu Ke-Xiang; Li Yu-Min; Li Xun; Zhou Wen-Ce; Shan Yong; Liu Tao
Journal: Mol Biol Rep Date: 2011-05-12 Impact factor: 2.316

p53 mutants: the achilles' heel of human cancers?

1. Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.

2. The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.

3. Study on the association of p53 codon 72 polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu Province in China.

4. A p53 genetic polymorphism of gastric cancer: difference between early gastric cancer and advanced gastric cancer.

5. Heterogeneous biomedical database integration using a hybrid strategy: a p53 cancer research database.

6. Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.

7. Novel p53 codon 240 Ser > Thr coding region mutation in the patients of oral squamous cell carcinoma (OSCC).

8. microRNAs: short non-coding bullets of gain of function mutant p53 proteins.

9. Predicting positive p53 cancer rescue regions using Most Informative Positive (MIP) active learning.