| Literature DB >> 15280544 |
Peter Korakas1, Stuart Chaffee, J Brad Shotwell, Pamela Duque, John L Wood.
Abstract
Securamine A is a structurally intriguing alkaloid possessing a pyrroloindole core joined via a modified isoprene subunit to a functionalized imidazole ring. Recent synthetic efforts in this laboratory have resulted in the efficient construction of key lactone 36, which undergoes tandem azide reduction/ring expansion to macrolactam 37. Macrolactam 37 possesses the complete macrocyclic core of securamine A.Entities:
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Year: 2004 PMID： 15280544 PMCID： PMC514433 DOI： 10.1073/pnas.0402274101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205