Literature DB >> 15280324

"Promiscuous" anticancer drugs that hit multiple targets may thwart resistance.

Tracy Hampton.   

Abstract

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Year:  2004        PMID： 15280324     DOI： 10.1001/jama.292.4.419

Source DB:  PubMed          Journal:  JAMA        ISSN： 0098-7484            Impact factor:   56.272


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  9 in total

1.  A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Authors:  Mingzhao Zhu; Wayne D Harshbarger; Omar Robles; Joanna Krysiak; Kenneth G Hull; Sung Wook Cho; Robyn D Richardson; Yanyan Yang; Andres Garcia; Lindsey Spiegelman; Bianca Ramirez; Christopher T Wilson; Ju Anne Yau; James T Moore; Caitlen B Walker; James C Sacchettini; Wenshe R Liu; Stephan A Sieber; Jeffrey W Smith; Daniel Romo
Journal:  Bioorg Med Chem       Date:  2017-01-19       Impact factor: 3.641

2.  Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.

Authors:  Delphine Lamoral-Theys; Laurent Pottier; Frédéric Kerff; François Dufrasne; Fabien Proutière; Nathalie Wauthoz; Philippe Neven; Laurent Ingrassia; Pierre Van Antwerpen; Florence Lefranc; Michel Gelbcke; Bernard Pirotte; Jean-Louis Kraus; Jean Nève; Alexander Kornienko; Robert Kiss; Jacques Dubois
Journal:  Bioorg Med Chem       Date:  2010-04-21       Impact factor: 3.641

3.  IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

Authors:  J K Cheong; T H Nguyen; H Wang; P Tan; P M Voorhoeve; S H Lee; D M Virshup
Journal:  Oncogene       Date:  2011-01-24       Impact factor: 9.867

4.  Tinnitus: network pathophysiology-network pharmacology.

Authors:  Ana B Elgoyhen; Berthold Langguth; Sven Vanneste; Dirk De Ridder
Journal:  Front Syst Neurosci       Date:  2012-01-25

Review 5.  Promiscuous drugs compared to selective drugs (promiscuity can be a virtue).

Authors:  Simon K Mencher; Long G Wang
Journal:  BMC Clin Pharmacol       Date:  2005-04-26

6.  Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery.

Authors:  Hong-Fang Ji; De-Xin Kong; Liang Shen; Ling-Ling Chen; Bin-Guang Ma; Hong-Yu Zhang
Journal:  Genome Biol       Date:  2007       Impact factor: 13.583

7.  Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology.

Authors:  Roeland van Wijk; Sander J Tans; Pieter Rein ten Wolde; Alireza Mashaghi
Journal:  Sci Rep       Date:  2015-06-18       Impact factor: 4.379

8.  Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets.

Authors:  Reagan M Mogire; Hoseah M Akala; Rosaline W Macharia; Dennis W Juma; Agnes C Cheruiyot; Ben Andagalu; Mathew L Brown; Hany A El-Shemy; Steven G Nyanjom
Journal:  PLoS One       Date:  2017-10-31       Impact factor: 3.240

9.  Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR.

Authors:  Dilip Narayanan; Osman A B S M Gani; Franz X E Gruber; Richard A Engh
Journal:  J Cheminform       Date:  2017-07-04       Impact factor: 5.514
  9 in total

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