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Literature DB >> 15280241

The Mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster.

Marina Karakozova¹, Ekaterina Savitskaya, Larisa Melnikova, Aleksandr Parshikov, Pavel Georgiev.

Abstract

Transposable element P of Drosophila melanogaster is one of the best-characterized eukaryotic transposons. Successful transposition requires the interaction between transposase complexes at both termini of the P element. Here we found that insertion of one or two copies of the Su(Hw) insulator in the P transposon reduces the frequency of its transposition. Inactivation of a Mod(mdg4) component of the Su(Hw) insulator suppresses the insulator effect. Thus, the Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells.

Entities: Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15280241 PMCID： PMC1470935 DOI： 10.1534/genetics.104.027037

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

34 in total

1. The gypsy insulators flanking yellow enhancers do not form a separate transcriptional domain in Drosophila melanogaster: the enhancers can activate an isolated yellow promoter.

Authors: Larisa Melnikova; Maria Gause; Pavel Georgiev
Journal: Genetics Date: 2002-04 Impact factor: 4.562

2. Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila.

Authors: Fabien Mongelard; Mariano Labrador; Ellen M Baxter; Tatiana I Gerasimova; Victor G Corces
Journal: Genetics Date: 2002-04 Impact factor: 4.562

Review 3. Insulators: many functions, many mechanisms.

Authors: Adam G West; Miklos Gaszner; Gary Felsenfeld
Journal: Genes Dev Date: 2002-02-01 Impact factor: 11.361

4. Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function.

Authors: D Ghosh; T I Gerasimova; V G Corces
Journal: EMBO J Date: 2001-05-15 Impact factor: 11.598

Review 5. Genomic insulators: connecting properties to mechanism.

Authors: Emily J Kuhn; Pamela K Geyer
Journal: Curr Opin Cell Biol Date: 2003-06 Impact factor: 8.382

Review 6. Protecting against promiscuity: the regulatory role of insulators.

Authors: P K Geyer; I Clark
Journal: Cell Mol Life Sci Date: 2002-12 Impact factor: 9.261

7. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins.

Authors: M Gause; P Morcillo; D Dorsett
Journal: Mol Cell Biol Date: 2001-07 Impact factor: 4.272

8. Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome.

Authors: K O'Hare; G M Rubin
Journal: Cell Date: 1983-08 Impact factor: 41.582

The Mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster.

1. The gypsy insulators flanking yellow enhancers do not form a separate transcriptional domain in Drosophila melanogaster: the enhancers can activate an isolated yellow promoter.

2. Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila.

Review 3. Insulators: many functions, many mechanisms.

4. Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function.

Review 5. Genomic insulators: connecting properties to mechanism.

Review 6. Protecting against promiscuity: the regulatory role of insulators.

7. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins.

8. Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome.

9. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.

10. A test of insulator interactions in Drosophila.

1. A study of the structure of 1A2 insulator of Drosophila melanogaster.

2. Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.