Literature DB >> 15279902

Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.

Soon Young Shin1, Chang Gun Kim, Eek-Hoon Jho, Myung-Sun Rho, Yong Sik Kim, Young-Ho Kim, Young Han Lee.   

Abstract

The Wnt signal transduction pathway plays an important role in organogenesis and carcinogenesis. In an effort to better understand the action of oxidative stress-induced cellular signaling, we investigate the effect of exogenous H2O2 on the Wnt signal pathway. H2O2 decreases the amount of nuclear beta-catenin and Tcf/Lef-dependent transcription. Overexpression of Dvl-1 abrogated H2O2-induced downregulation of beta-catenin. Pretreatment with LiCl or Wnt-3a conditioned medium completely inhibited H2O2-induced release of mitochondrial cytochrome c and DNA fragmentation. These results suggest that H2O2 negatively modulates the Wnt signal pathway through downregulation of beta-catenin.

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Year:  2004        PMID： 15279902     DOI： 10.1016/j.canlet.2004.03.003

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  37 in total

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