Literature DB >> 15279795

The emerging role of E2F-1 in the DNA damage response and checkpoint control.

Craig Stevens1, Nicholas B La Thangue.   

Abstract

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.

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Year:  2004        PMID： 15279795     DOI： 10.1016/j.dnarep.2004.03.034

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  51 in total

1.  A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis.

Authors:  Bing Wang; Kang Liu; Fang-Tsyr Lin; Weei-Chin Lin
Journal:  J Biol Chem       Date:  2004-10-19       Impact factor: 5.157

2.  Adenoviral-E2F-1 radiosensitizes p53wild-type and p53null human prostate cancer cells.

Authors:  Khanh H Nguyen; Paul Hachem; Li-Yan Khor; Naji Salem; Kelly K Hunt; Peter R Calkins; Alan Pollack
Journal:  Int J Radiat Oncol Biol Phys       Date:  2005-09-01       Impact factor: 7.038

3.  Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.

Authors:  C D Hurst; D C Tomlinson; S V Williams; F M Platt; M A Knowles
Journal:  Oncogene       Date:  2007-11-26       Impact factor: 9.867

4.  RhoBTB2 (DBC2) is a mitotic E2F1 target gene with a novel role in apoptosis.

Authors:  Scott N Freeman; Yihong Ma; W Douglas Cress
Journal:  J Biol Chem       Date:  2007-11-26       Impact factor: 5.157

5.  The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair.

Authors:  Patrick S Lin; Lisa A McPherson; Aubrey Y Chen; Julien Sage; James M Ford
Journal:  DNA Repair (Amst)       Date:  2009-04-18

Review 6.  Autophagy and genomic integrity.

Authors:  A T Vessoni; E C Filippi-Chiela; C Fm Menck; G Lenz
Journal:  Cell Death Differ       Date:  2013-08-09       Impact factor: 15.828

7.  Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue.

Authors:  Brian J Albert; Ananthapadmanabhan Sivaramakrishnan; Tadaatsu Naka; Nancy L Czaicki; Kazunori Koide
Journal:  J Am Chem Soc       Date:  2007-02-06       Impact factor: 15.419

8.  Functional interplay between E2F1 and chemotherapeutic drugs defines immediate E2F1 target genes crucial for cancer cell death.

Authors:  David Engelmann; Susanne Knoll; Daniel Ewerth; Marc Steder; Anja Stoll; Brigitte M Pützer
Journal:  Cell Mol Life Sci       Date:  2009-12-15       Impact factor: 9.261

9.  pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737.

Authors:  J Bertin-Ciftci; B Barré; J Le Pen; L Maillet; C Couriaud; P Juin; F Braun
Journal:  Cell Death Differ       Date:  2013-02-22       Impact factor: 15.828

10.  DNA-damage response control of E2F7 and E2F8.

Authors:  L Panagiotis Zalmas; Xiujie Zhao; Anne L Graham; Rebecca Fisher; Carmel Reilly; Amanda S Coutts; Nicholas B La Thangue
Journal:  EMBO Rep       Date:  2008-01-18       Impact factor: 8.807
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