| Literature DB >> 15278363 |
Maja Grabacka1, Wojciech Placha, Przemyslaw M Plonka, Stanislawa Pajak, Krystyna Urbanska, Piotr Laidler, Andrzej Slominski.
Abstract
The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) alpha, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR alpha in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention. Copyright 2004 Springer-VerlagEntities:
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Year: 2004 PMID： 15278363 DOI： 10.1007/s00403-004-0479-y
Source DB: PubMed Journal: Arch Dermatol Res ISSN： 0340-3696 Impact factor: 3.017