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Literature DB >> 15276706

Are synaptic MAGUK proteins involved in chronic pain?

Abstract

Chronic pain, particularly neuropathic pain, is notoriously difficult to treat. NMDA receptor antagonists are effective in reducing pain hypersensitivity in animal models and clinical settings but are associated with an unacceptable level of side-effects. Recent studies of the role of a family of synaptic membrane-associated guanylate kinase proteins in chronic pain provide new insights into central mechanisms of chronic pain that could result in new biochemical targets for its treatment.

Entities: Disease

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Year: 2004 PMID： 15276706 DOI： 10.1016/j.tips.2004.06.004

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

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Cited

7 in total

1. A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.

Authors: Dorina Saro; Tao Li; Chamila Rupasinghe; Azrael Paredes; Nicole Caspers; Mark R Spaller
Journal: Biochemistry Date: 2007-05-03 Impact factor: 3.162

2. PDZ domains at excitatory synapses: potential molecular targets for persistent pain treatment.

Authors: Yuan-Xiang Tao; Roger A Johns
Journal: Curr Neuropharmacol Date: 2006-07 Impact factor: 7.363

3. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.

Authors: Sylvie Bradesi; Viktoriya Golovatscka; Helena S Ennes; James A McRoberts; Iordanes Karagiannides; Iordanes Karagiannidis; Kyriaki Bakirtzi; Charalabos Pothoulakis; Emeran A Mayer
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2011-06-30 Impact factor: 4.052

7. Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity.

Authors: M Zhang; J T Xu; X Zhu; Z Wang; X Zhao; Z Hua; Y X Tao; Y Xu
Journal: Neuroscience Date: 2010-01-25 Impact factor: 3.590

7 in total

Are synaptic MAGUK proteins involved in chronic pain?

1. A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.

2. PDZ domains at excitatory synapses: potential molecular targets for persistent pain treatment.

3. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.

4. Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts.

5. A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia.

6. Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1.

7. Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity.