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Literature DB >> 15276642

Interaction of ACE2 and integrin beta1 in failing human heart.

Qishan Lin¹, Rebecca S Keller, Barbara Weaver, Lawrence S Zisman.

Abstract

ACE2 purified from failing human heart was found to form a complex with integrin beta1 by immunoprecipitation, Western blotting, activity assay, and ESI tandem mass spectroscopy. The ACE2/integrin complex showed a Km of 6.8 microM and a Vmax of 2.13 pmol/min/microl purified enzyme. Activity was optimal at pH 7.5 with Ang II substrate.

Entities: Gene Species

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Year: 2004 PMID： 15276642 DOI： 10.1016/j.bbadis.2004.05.005

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

16 in total

1. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.

Authors: Sreedhar Bodiga; Jiu Chang Zhong; Wang Wang; Ratnadeep Basu; Jennifer Lo; George C Liu; Danny Guo; Steven M Holland; James W Scholey; Josef M Penninger; Zamaneh Kassiri; Gavin Y Oudit
Journal: Cardiovasc Res Date: 2011-02-01 Impact factor: 10.787

2. Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling.

Authors: Nicola E Clarke; Martin J Fisher; Karen E Porter; Daniel W Lambert; Anthony J Turner
Journal: PLoS One Date: 2012-04-16 Impact factor: 3.240

3. Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist.

Authors: Emma G Norris; Xuan Sabrina Pan; Denise C Hocking
Journal: bioRxiv Date: 2022-04-11

Review 4. Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease.

Authors: Carlos M Ferrario; Sarfaraz Ahmad; Leanne Groban
Journal: Clin Sci (Lond) Date: 2020-10-16 Impact factor: 6.876

5. New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection.

Authors: Shijia Yan; Haixia Sun; Xianzhang Bu; Guohui Wan
Journal: Front Pharmacol Date: 2020-06-12 Impact factor: 5.810

Interaction of ACE2 and integrin beta1 in failing human heart.

1. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.

2. Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling.

3. Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist.

Review 4. Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease.

5. New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection.

6. ACE and ACE2: a tale of two enzymes.

7. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.

Review 8. Angiotensin-converting enzyme 2 as a therapeutic target for heart failure.

9. Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung.

Review 10. Not just angiotensinases: new roles for the angiotensin-converting enzymes.