Literature DB >> 15276302

Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine.

Fazlul Huq1, Hassan Daghriri, Jun Qing Yu, Philip Beale, Keith Fisher.   

Abstract

Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH(3))Cl(2) where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer activity against human cancer cell lines. YH12 is found to be significantly more active than cisplatin against cisplatin-resistant ovary cell line A2780(cisR).

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Year:  2004        PMID： 15276302     DOI： 10.1016/j.ejmech.2004.04.005

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  2 in total

1.  3-Hydroxypyridine Dehydrogenase HpdA Is Encoded by a Novel Four-Component Gene Cluster and Catalyzes the First Step of 3-Hydroxypyridine Catabolism in Ensifer adhaerens HP1.

Authors:  Haixia Wang; Xiaoyu Wang; Hao Ren; Xuejun Wang; Zhenmei Lu
Journal:  Appl Environ Microbiol       Date:  2020-09-17       Impact factor: 4.792

2.  Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine.

Authors:  Ahmed Abdullah; Fazlul Huq; Ashraf Chowdhury; Hasan Tayyem; Philip Beale; Keith Fisher
Journal:  BMC Chem Biol       Date:  2006-03-13
  2 in total

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