Literature DB >> 15276180

MT1-MMP: an enzyme with multidimensional regulation.

Yoshifumi Itoh1, Motoharu Seiki.   

Abstract

The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.

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Year:  2004        PMID： 15276180     DOI： 10.1016/j.tibs.2004.04.001

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  30 in total

1.  A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis.

Authors:  Hyejin Lee; Christopher M Overall; Christopher A McCulloch; Jaro Sodek
Journal:  Mol Biol Cell       Date:  2006-09-13       Impact factor: 4.138

Review 2.  Probing cellular microenvironments and tissue remodeling by atomic force microscopy.

Authors:  Thomas Ludwig; Robert Kirmse; Kate Poole; Ulrich S Schwarz
Journal:  Pflugers Arch       Date:  2007-12-06       Impact factor: 3.657

3.  c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site.

Authors:  Martin Baumgartner; Gerald Radziwill; Mihaela Lorger; Andreas Weiss; Karin Moelling
Journal:  Mol Cell Biol       Date:  2007-11-26       Impact factor: 4.272

4.  Changes in gene-expression profiles of colon carcinoma cells induced by wild type K-ras2.

Authors:  Hong Li; Hou-Fa Cao; Yuan Li; Mei-Ling Zhu; Jun Wan
Journal:  World J Gastroenterol       Date:  2007-09-14       Impact factor: 5.742

5.  Targeting the MMP-14/MMP-2/integrin αvβ3 axis with multispecific N-TIMP2-based antagonists for cancer therapy.

Authors:  Gal Yosef; Valeria Arkadash; Niv Papo
Journal:  J Biol Chem       Date:  2018-07-09       Impact factor: 5.157

Review 6.  Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting.

Authors:  George E Davis; Amber N Stratman; Anastasia Sacharidou; Wonshill Koh
Journal:  Int Rev Cell Mol Biol       Date:  2011       Impact factor: 6.813

7.  Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events.

Authors:  Anastasia Sacharidou; Wonshill Koh; Amber N Stratman; Anne M Mayo; Kevin E Fisher; George E Davis
Journal:  Blood       Date:  2010-03-09       Impact factor: 22.113

8.  Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2.

Authors:  Sharon Elliot; Paola Catanuto; William Stetler-Stevenson; Scott W Cousins
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-04       Impact factor: 4.799

Review 9.  The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion.

Authors:  Peter Neth; Christian Ries; Marisa Karow; Virginia Egea; Matthias Ilmer; Marianne Jochum
Journal:  Stem Cell Rev       Date:  2007-01       Impact factor: 5.739

10.  The cytoplasmic tail dileucine motif LL572 determines the glycosylation pattern of membrane-type 1 matrix metalloproteinase.

Authors:  Thomas Ludwig; Sarah M Theissen; Michael J Morton; Michael J Caplan
Journal:  J Biol Chem       Date:  2008-10-27       Impact factor: 5.157
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