Literature DB >> 15275774

Antinociceptive mechanism of L-DOPA.

Takao Shimizu1, Shin-ichi Iwata, Hirofumi Morioka, Takasi Masuyama, Takeo Fukuda, Masahiro Nomoto.   

Abstract

The mechanism of L-DOPA for antinociception was investigated. Nociceptive behaviors in mice after an intrathecal (i.t.) administration of substance P were evaluated. L-DOPA (i.t.) dose-dependently attenuated the substance P-induced nociceptive behaviors. Co-administration of benserazide (i.t.), a DOPA decarboxylase inhibitor, abolished the antinociceptive effect of L-DOPA. The L-DOPA-induced antinociception was antagonized by sulpiride, a D2 blocker, but not by SCH 23390, a D1 blocker. These results suggest that L-DOPA relieves pain after conversion to dopamine, with the dopamine sedating pain transmission by way of the dopamine D2 receptor.

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Year:  2004        PMID： 15275774     DOI： 10.1016/j.pain.2004.03.038

Source DB:  PubMed          Journal:  Pain        ISSN： 0304-3959            Impact factor:   6.961


  11 in total

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4.  Nociceptive Response to L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats.

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