Literature DB >> 15275423

Coenzyme Q homologs in parasitic protozoa as targets for chemotherapeutic attack.

J E Ellis1.   

Abstract

The central role of coenzyme Q (ubiquinone) in cellular energy metabolism is well established. Recent work has implicated this molecule in a wide range of other cellular functions, including roles in growth control, plasma membrane oxidase and as a cellular antioxidant. In this review, Jayne Ellis presents an overview of the current knowledge of this important cellular component in species of parasitic protozoa, discusses current therapies using its analogs and proposes its potential roles in these organisms.

Entities:  

Year:  1994        PMID： 15275423     DOI： 10.1016/0169-4758(94)90079-5

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  13 in total

1.  Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.

Authors:  M T Cushion; M Collins; B Hazra; E S Kaneshiro
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  Ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of Pneumocystis spp.: differential sensitivities to atovaquone.

Authors:  Mireille Basselin; Shannon M Hunt; Hiam Abdala-Valencia; Edna S Kaneshiro
Journal:  Eukaryot Cell       Date:  2005-08

3.  Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.

Authors:  Giancarlo A Biagini; Parnpen Viriyavejakul; Paul M O'neill; Patrick G Bray; Stephen A Ward
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

4.  Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases.

Authors:  Ahmad Saleh; Johannes Friesen; Stefan Baumeister; Uwe Gross; Wolfgang Bohne
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

Review 5.  The lipids of Pneumocystis carinii.

Authors:  E S Kaneshiro
Journal:  Clin Microbiol Rev       Date:  1998-01       Impact factor: 26.132

6.  Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in Malaria.

Authors:  I B Verdaguer; M Crispim; C A Zafra; R A C Sussmann; N L Buriticá; H R Melo; M F Azevedo; F G Almeida; E A Kimura; A M Katzin
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

7.  Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units.

Authors:  A S Couto; E A Kimura; V J Peres; M L Uhrig; A M Katzin
Journal:  Biochem J       Date:  1999-08-01       Impact factor: 3.857

8.  Effects of atovaquone and diospyrin-based drugs on ubiquinone biosynthesis in Pneumocystis carinii organisms.

Authors:  E S Kaneshiro; D Sul; B Hazra
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

Review 9.  Parasite powerhouse: A review of the Toxoplasma gondii mitochondrion.

Authors:  Madelaine M Usey; Diego Huet
Journal:  J Eukaryot Microbiol       Date:  2022-03-21       Impact factor: 3.880

10.  Synthesis, leishmanicidal activity and theoretical evaluations of a series of substituted bis-2-hydroxy-1,4-naphthoquinones.

Authors:  Morgana V de Araújo; Patricia S O de Souza; Aline C de Queiroz; Carolina B B da Matta; Anderson Brandão Leite; Amanda Evelyn da Silva; José A A de França; Tania M S Silva; Celso A Camara; Magna S Alexandre-Moreira
Journal:  Molecules       Date:  2014-09-22       Impact factor: 4.411
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