Models for malaria: Nature knows best.

Despite our increasing knowledge of the immunology of malaria in humans and in experimental systems, many questions remain unanswered. Given that this research has not yet led to a successful bloodstage vaccine, perhaps we should look again more carefully, in the light of new knowledge, at how many natural malaria infections are successfully controlled. Of these, the simian malarias are probably the most interesting, as described here by Geoff Butcher.