Literature DB >> 15275076

The acquisition of purines by trypanosomatids.

C S Cohn1, M Gottlieb.   

Abstract

Parasites of the family Trypanosomatidae have an absolute requirement for purines, yet lack the intracellular machinery to synthesize their own purine ring de novo. As a result, the enzymes devoted to the transport and metabolism of purines are extremely important to the parasite. Here, Claudia Cohn and Michael Gottlieb emphasize the value of understanding purine salvage for the development of trypanocidal drugs, and discuss the putative transporters devoted to purine uptake.

Entities:  

Year:  1997        PMID： 15275076     DOI： 10.1016/s0169-4758(97)01059-4

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  8 in total

1.  Episomally driven antisense mRNA abrogates the hyperinducible expression and function of a unique cell surface class I nuclease in the primitive trypanosomatid parasite, Crithidia luciliae.

Authors:  Mat Yamage; Manju B Joshi; Dennis M Dwyer
Journal:  J Mol Biol       Date:  2007-08-21       Impact factor: 5.469

2.  Magnesium-Dependent Ecto-ATP Diphosphohydrolase Activity in Leishmania donovani.

Authors:  Preeti Sinha; Ranjeet Kumar Paswan; Anjali Kumari; Sanjay Kumar; Sanjeeva Bimal; Pradeep Das; Chandra Shekhar Lal
Journal:  Curr Microbiol       Date:  2016-09-02       Impact factor: 2.188

3.  Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.

Authors:  Diana Ortiz; Raquel Valdés; Marco A Sanchez; Johanna Hayenga; Carolyn Elya; Siegfried Detke; Scott M Landfear
Journal:  Mol Microbiol       Date:  2010-08-02       Impact factor: 3.501

Review 4.  Possible effects of microbial ecto-nucleoside triphosphate diphosphohydrolases on host-pathogen interactions.

Authors:  Fiona M Sansom; Simon C Robson; Elizabeth L Hartland
Journal:  Microbiol Mol Biol Rev       Date:  2008-12       Impact factor: 11.056

5.  Leishmania infantum ecto-nucleoside triphosphate diphosphohydrolase-2 is an apyrase involved in macrophage infection and expressed in infected dogs.

Authors:  Raphael De Souza Vasconcellos; Christiane Mariotini-Moura; Rodrigo Saar Gomes; Tiago Donatelli Serafim; Rafaela de Cássia Firmino; Matheus Silva E Bastos; Felipe Freitas de Castro; Claudia Miranda de Oliveira; Lucas Borges-Pereira; Anna Cláudia Alves de Souza; Ronny Francisco de Souza; Gabriel Andres Tafur Gómez; Aimara da Costa Pinheiro; Talles Eduardo Ferreira Maciel; Abelardo Silva-Júnior; Gustavo Costa Bressan; Márcia Rogéria Almeida; Munira Muhammad Abdel Baqui; Luís Carlos Crocco Afonso; Juliana Lopes Rangel Fietto
Journal:  PLoS Negl Trop Dis       Date:  2014-11-13

6.  Modeling Immune Response to Leishmania Species Indicates Adenosine As an Important Inhibitor of Th-Cell Activation.

Authors:  Henrique A L Ribeiro; Tatiani U Maioli; Leandro M de Freitas; Paolo Tieri; Filippo Castiglione
Journal:  Front Cell Infect Microbiol       Date:  2017-07-20       Impact factor: 5.293

7.  Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromolar Affinity.

Authors:  Thaís Viana Fialho Martins; Ana Eliza Zeraik; Natália Oliveira Alves; Leandro Licursi de Oliveira; Tiago Antônio de Oliveira Mendes; Ricardo DeMarco; Eduardo de Almeida Marques-da-Silva
Journal:  Bioinform Biol Insights       Date:  2018-03-13

8.  Nucleoside triphosphate diphosphohydrolase1 (TcNTPDase-1) gene expression is increased due to heat shock and in infective forms of Trypanosoma cruzi.

Authors:  Natália Lins Silva-Gomes; Vitor Ennes-Vidal; Julliane Castro Ferreira Carolo; Marcos Meuser Batista; Maria Nazaré Soeiro; Rubem Menna-Barreto; Otacilio Cruz Moreira
Journal:  Parasit Vectors       Date:  2014-10-05       Impact factor: 3.876
  8 in total

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