| Literature DB >> 15274557 |
M V Kitaeva1, N S Melik-Nubarov, F M Menger, A A Yaroslavov.
Abstract
Complexation of antitumor drug, doxorubicin (DOX), with poly(acrylic acid) (PAA) in buffer solutions was examined. The DOX-to-PAA binding was governed by electrostatic and stacking interactions resulting in a complex of characteristic composition with a PAA/DOX = 1.6 molar ratio. Sizes of the complex particles were found to lie in 600-900-nm range. However, the particles were able to interact with small neutral egg yolk lecithin liposomes (80-100 nm in diameter), a ternary DOX/PAA/liposome complex being formed. The observations and conclusions we made may be useful for interpreting biological effects of polymer-based bioactive constructs.Entities:
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Year: 2004 PMID： 15274557 DOI： 10.1021/la0497144
Source DB: PubMed Journal: Langmuir ISSN： 0743-7463 Impact factor: 3.882