AIM: To investigate the role of CD44s in the biological behavior of surface epithelial ovarian tumors and its correlation with clinicopathological parameters, prognosis, p53, steroid receptor status and proliferative indices (PCNA, MIB1). MATERIALS AND METHODS: We analyzed a total of 83 patients with ovarian surface epithelial tumors, for the immunohistochemical expression of CD44s and the possible correlation with clinicopathological factors and patients' outcome. RESULTS: A statistically significant correlation was found between the expression of CD44s, which was higher in cancer cases than in benign cystadenomas (p<0.0001) and, between cancer cases, which was lower in borderline tumors, (p=0.05). No statistical correlation was found between CD44s expression and the examined markers. In overall survival analysis we did not detect a statistically significant correlation with the expression of CD44s. CONCLUSION: The current study demonstrates that CD44s may be functionally involved in the pathogenesis of epithelial ovarian lesions.
AIM: To investigate the role of CD44s in the biological behavior of surface epithelial ovarian tumors and its correlation with clinicopathological parameters, prognosis, p53, steroid receptor status and proliferative indices (PCNA, MIB1). MATERIALS AND METHODS: We analyzed a total of 83 patients with ovarian surface epithelial tumors, for the immunohistochemical expression of CD44s and the possible correlation with clinicopathological factors and patients' outcome. RESULTS: A statistically significant correlation was found between the expression of CD44s, which was higher in cancer cases than in benign cystadenomas (p<0.0001) and, between cancer cases, which was lower in borderline tumors, (p=0.05). No statistical correlation was found between CD44s expression and the examined markers. In overall survival analysis we did not detect a statistically significant correlation with the expression of CD44s. CONCLUSION: The current study demonstrates that CD44s may be functionally involved in the pathogenesis of epithelial ovarian lesions.
Authors: Alaa A Elzarkaa; Bassma El Sabaa; Doaa Abdelkhalik; Hassan Mansour; Mahmoud Melis; Waleed Shaalan; Mohamed Farouk; Eduard Malik; Amr A Soliman Journal: J Cancer Res Clin Oncol Date: 2016-01-13 Impact factor: 4.553