Literature DB >> 15273740

AMID is a p53-inducible gene downregulated in tumors.

Min Wu1, Liang-Guo Xu, Tian Su, Yang Tian, Zhonghe Zhai, Hong-Bing Shu.   

Abstract

AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that p53 could bind to human AMID promoter. Deletion mutagenesis indicated that human AMID promoter contains two p53-responsive elements. Furthermore, expression array analysis indicated that human AMID mRNA expression was downregulated in a majority of human tumors. Our findings point to the possibility that AMID is a p53-downstream gene involved in tumorigenesis.

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Year:  2004        PMID： 15273740     DOI： 10.1038/sj.onc.1207909

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  14 in total

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Journal:  Cell Physiol Biochem       Date:  2011-02-11

4.  The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.

Authors:  Yue Zhang; Zhifang Xu; Wen Wen; Zhichao Liu; Chao Zhang; Ming Li; Fengping Hu; Shi Wei; Sejong Bae; Jiangbing Zhou; Runhua Liu; Lizhong Wang
Journal:  Oncogene       Date:  2022-05-02       Impact factor: 8.756

Review 5.  SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

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Review 6.  ROS-Dependent Lipid Peroxidation and Reliant Antioxidant Ferroptosis-Suppressor-Protein 1 in Rheumatoid Arthritis: a Covert Clue for Potential Therapy.

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8.  Impact of Alu repeats on the evolution of human p53 binding sites.

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Journal:  Biol Direct       Date:  2011-01-06       Impact factor: 4.540

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Journal:  PLoS One       Date:  2012-03-28       Impact factor: 3.240

10.  The transcription factor p53: not a repressor, solely an activator.

Authors:  Martin Fischer; Lydia Steiner; Kurt Engeland
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534
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