Literature DB >> 15273133

Lack of activity of orally administered clofazimine against intracellular Mycobacterium tuberculosis in whole-blood culture.

Ernestas Janulionis1, Carolina Sofer, Ho-Yeon Song, Robert S Wallis.   

Abstract

The activity of oral clofazimine against intracellular Mycobacterium tuberculosis was compared to that of ofloxacin in healthy volunteers by the use of whole-blood cultures. Clofazimine was inactive whether it was tested alone or combined with other drugs that are used to treat multidrug-resistant tuberculosis, despite a total dose of 2 g. Kanamycin was the most active drug tested.

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Year:  2004        PMID： 15273133      PMCID： PMC478499          DOI： 10.1128/AAC.48.8.3133-3135.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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