| Literature DB >> 15272396 |
Guowei Fang1, Carla Kuiken, Barbara Weiser, Sarah Rowland-Jones, Francis Plummer, Chih-Hsiung Chen, Rupert Kaul, Aggrey Omu Anzala, Job Bwayo, Joshua Kimani, Sean M Philpott, Christina Kitchen, Janet S Sinsheimer, Brian Gaschen, Dorothy Lang, Binshan Shi, Kimdar Sherefa Kemal, Tim Rostron, Cheryl Brunner, Simon Beddows, Quentin Sattenau, Ellen Paxinos, Julius Oyugi, Harold Burger.
Abstract
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.Entities:
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Year: 2004 PMID： 15272396 DOI： 10.1086/421504
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226