Literature DB >> 15272283

p185HER2 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's disease.

Olaf Reich1, Bernadette Liegl, Karl Tamussino, Sigrid Regauer.   

Abstract

We evaluated p186Her2 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's disease. We identified six patients with recurrent vulvar Paget's disease in our archives. The number of recurrences ranged from 1 to 11 over a time period of 1-168 months. Recurrences were evaluated immunohistochemically for p185Her2 overexpression with the HercepTest and for HER2 oncogene amplification with fluorescence in situ hybridization. p185Her2 overexpression was scored as 3 in two patients, as 2 in two patients, and as 1 in two patients. All patients with scores 2 and 3 showed HER2 oncogene amplification. Overexpression of p185Her2 and HER2 oncogene amplification appears to be common in recurrent vulvar Paget's disease.

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Year:  2005        PMID： 15272283     DOI： 10.1038/modpathol.3800243

Source DB:  PubMed          Journal:  Mod Pathol        ISSN： 0893-3952            Impact factor:   7.842


  4 in total

1.  The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) Consensus Statements on Pre-invasive Vulvar Lesions.

Authors:  Mario Preti; Elmar Joura; Pedro Vieira-Baptista; Marc Van Beurden; Federica Bevilacqua; Maaike C G Bleeker; Jacob Bornstein; Xavier Carcopino; Cyrus Chargari; Margaret E Cruickshank; Bilal Emre Erzeneoglu; Niccolò Gallio; Debra Heller; Vesna Kesic; Olaf Reich; Colleen K Stockdale; Bilal Esat Temiz; Linn Woelber; François Planchamp; Jana Zodzika; Denis Querleu; Murat Gultekin
Journal:  J Low Genit Tract Dis       Date:  2022-06-21       Impact factor: 3.842

2.  Extramammary Paget's disease in Chinese males: a 21-year experience.

Authors:  Tor W Chiu; Pauline S Y Wong; Kawser Ahmed; Stephanie C K Lam; Shun Y Ying; Andrew Burd
Journal:  World J Surg       Date:  2007-10       Impact factor: 3.282

3.  Human Epidermal Growth Factor Receptor 2 (HER-2/neu)-Directed Therapy for Rare Metastatic Epithelial Tumors with HER-2 Amplification.

Authors:  Daniel Sanghoon Shin; Timothy Sherry; Michael E Kallen; Steven Wong; Alexandra Drakaki
Journal:  Case Rep Oncol       Date:  2016-06-11

4.  Human epidermal growth factor receptor 2 amplification as a biomarker for treatment in patients with lymph node-metastatic penoscrotal extramammary Paget's disease.

Authors:  Xiaolin Lu; Peipei Zhang; Yao Zhu; Dingwei Ye
Journal:  Oncol Lett       Date:  2019-01-14       Impact factor: 2.967
  4 in total

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