Literature DB >> 15272270

Genetic clues to the pathogenesis of Parkinson's disease.

Miquel Vila1, Serge Przedborski.   

Abstract

Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the disorder.

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Year:  2004        PMID： 15272270     DOI： 10.1038/nm1068

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  72 in total

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2.  Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain.

Authors:  Erica L Beatman; Aaron Massey; Katherine D Shives; Kristina S Burrack; Mastooreh Chamanian; Thomas E Morrison; J David Beckham
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Review 3.  Reverse genetics for proteomics: from proteomic discovery to scientific content.

Authors:  M Bauer; M Ueffing
Journal:  J Neural Transm (Vienna)       Date:  2006-07-13       Impact factor: 3.575

4.  Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection.

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5.  Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.

Authors:  Antony A Cooper; Aaron D Gitler; Anil Cashikar; Cole M Haynes; Kathryn J Hill; Bhupinder Bhullar; Kangning Liu; Kexiang Xu; Katherine E Strathearn; Fang Liu; Songsong Cao; Kim A Caldwell; Guy A Caldwell; Gerald Marsischky; Richard D Kolodner; Joshua Labaer; Jean-Christophe Rochet; Nancy M Bonini; Susan Lindquist
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6.  DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.

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Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-31       Impact factor: 11.205

Review 7.  Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance.

Authors:  Chun Zhou; Yong Huang; Serge Przedborski
Journal:  Ann N Y Acad Sci       Date:  2008-12       Impact factor: 5.691

Review 8.  Therapeutic gene silencing in neurological disorders, using interfering RNA.

Authors:  G Scott Ralph; Nicholas D Mazarakis; Mimoun Azzouz
Journal:  J Mol Med (Berl)       Date:  2005-03-10       Impact factor: 4.599

9.  Coordination of copper to the membrane-bound form of α-synuclein.

Authors:  Christopher G Dudzik; Eric D Walter; Benjamin S Abrams; Melissa S Jurica; Glenn L Millhauser
Journal:  Biochemistry       Date:  2012-12-26       Impact factor: 3.162

10.  Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

Authors:  Eva Andres-Mateos; Rebeca Mejias; Masayuki Sasaki; Xiaojie Li; Brian M Lin; Saskia Biskup; Li Zhang; Rebecca Banerjee; Bobby Thomas; Lichuan Yang; Guosheng Liu; M Flint Beal; David L Huso; Ted M Dawson; Valina L Dawson
Journal:  J Neurosci       Date:  2009-12-16       Impact factor: 6.167
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