Michael E Mussolino1, Bruce S Jonas, Anne C Looker. 1. Centers for Disease Control and Prevention, National Center for Health Statistics, 3311 Toledo Road, Room 6431, Hyattsville, MD 20782, USA. MMussolino@cdc.gov
Abstract
OBJECTIVE: The purpose of this cross-sectional population-based study was to assess the association of major depressive episode (MDE) and dysthymia with bone mineral density (BMD) in young adults. METHODS: Data are from a nationally representative sample of 5,171 people aged 20 to 39 years from the Third National Health and Nutrition Examination Survey. Total proximal femoral BMD was measured using dual energy x-ray absorptiometry. MDE and dysthymia were measured using the Diagnostic Interview Schedule. RESULTS: MDE was associated with lower BMD in multivariate models in men (mean BMD = 1.038 vs. 1.068 g/cm(2); odds ratio (OR) per 1 SD decline in BMD = 1.65, 95% confidence interval (CI) = 1.08-2.52; p = 0.02) but not in women (mean BMD = 0.982 vs. 0.979 g/cm(2); OR = 0.96, 95% CI = 0.71-1.30; p =.79). The same divergence by gender was seen for dysthymia. CONCLUSION: The relationship between BMD and MDE or dysthymia in young adults varies by gender.
OBJECTIVE: The purpose of this cross-sectional population-based study was to assess the association of major depressive episode (MDE) and dysthymia with bone mineral density (BMD) in young adults. METHODS: Data are from a nationally representative sample of 5,171 people aged 20 to 39 years from the Third National Health and Nutrition Examination Survey. Total proximal femoral BMD was measured using dual energy x-ray absorptiometry. MDE and dysthymia were measured using the Diagnostic Interview Schedule. RESULTS: MDE was associated with lower BMD in multivariate models in men (mean BMD = 1.038 vs. 1.068 g/cm(2); odds ratio (OR) per 1 SD decline in BMD = 1.65, 95% confidence interval (CI) = 1.08-2.52; p = 0.02) but not in women (mean BMD = 0.982 vs. 0.979 g/cm(2); OR = 0.96, 95% CI = 0.71-1.30; p =.79). The same divergence by gender was seen for dysthymia. CONCLUSION: The relationship between BMD and MDE or dysthymia in young adults varies by gender.
Authors: Leslie Spangler; Delia Scholes; Robert L Brunner; John Robbins; Susan D Reed; Katherine M Newton; Jennifer L Melville; Andrea Z Lacroix Journal: J Gen Intern Med Date: 2008-02-20 Impact factor: 5.128
Authors: L-A Fraser; D Morrison; P Morley-Forster; T L Paul; S Tokmakejian; R Larry Nicholson; Y Bureau; T C Friedman; S H M Van Uum Journal: Exp Clin Endocrinol Diabetes Date: 2008-06-03 Impact factor: 2.949