Literature DB >> 15271958

Chlamydia pneumoniae decreases smooth muscle cell proliferation through induction of prostaglandin E2 synthesis.

Jürgen Rödel1, Dirk Prochnau, Katrin Prager, Jürgen Baumert, Karl-Hermann Schmidt, Eberhard Straube.   

Abstract

Chlamydia pneumoniae may modulate the proliferation of smooth muscle cells (SMC) in atherosclerotic plaques. Conditioned medium from C. pneumoniae-infected SMC decreased the proliferation of uninfected SMC. Treatment of infected cells with the cyclooxygenase-2 inhibitor NS-398 [N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide] suppressed the up-regulation of prostaglandin E(2) (PGE(2)) and abolished the antimitogenic effect of conditioned medium, suggesting that C. pneumoniae can decrease SMC proliferation via stimulation of PGE(2) synthesis.

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Year:  2004        PMID： 15271958      PMCID： PMC470606          DOI： 10.1128/IAI.72.8.4900-4904.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

Review 1.  Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role?

Authors:  J B Mahony; B K Coombes
Journal:  FEMS Microbiol Lett       Date:  2001-04-01       Impact factor: 2.742

Review 2.  Molecular mechanisms in intimal hyperplasia.

Authors:  A C Newby; A B Zaltsman
Journal:  J Pathol       Date:  2000-02       Impact factor: 7.996

3.  Inhibition of human arterial smooth muscle cell growth by human monocyte/macrophages: a co-culture study.

Authors:  D Proudfoot; C Fitzsimmons; J Torzewski; D E Bowyer
Journal:  Atherosclerosis       Date:  1999-07       Impact factor: 5.162

4.  Infection and activation of airway epithelial cells by Chlamydia pneumoniae.

Authors:  H U Jahn; M Krüll; F N Wuppermann; A C Klucken; S Rosseau; J Seybold; J H Hegemann; C A Jantos; N Suttorp
Journal:  J Infect Dis       Date:  2000-10-18       Impact factor: 5.226

Review 5.  Chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies.

Authors:  Jens Boman; Margaret R Hammerschlag
Journal:  Clin Microbiol Rev       Date:  2002-01       Impact factor: 26.132

6.  Adenylyl cyclase 3 mediates prostaglandin E(2)-induced growth inhibition in arterial smooth muscle cells.

Authors:  S T Wong; L P Baker; K Trinh; M Hetman; L A Suzuki; D R Storm; K E Bornfeldt
Journal:  J Biol Chem       Date:  2001-06-29       Impact factor: 5.157

7.  Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.

Authors:  S Sasu; D LaVerda; N Qureshi; D T Golenbock; D Beasley
Journal:  Circ Res       Date:  2001-08-03       Impact factor: 17.367

8.  Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.

Authors:  F Cipollone; C Prontera; B Pini; M Marini; M Fazia; D De Cesare; A Iezzi; S Ucchino; G Boccoli; V Saba; F Chiarelli; F Cuccurullo; A Mezzetti
Journal:  Circulation       Date:  2001-08-21       Impact factor: 29.690

9.  Production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells following infection with Chlamydia pneumoniae.

Authors:  J Rödel; M Woytas; A Groh; K H Schmidt; M Hartmann; M Lehmann; E Straube
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

10.  The catalytic domain of endogenous urokinase-type plasminogen activator is required for the mitogenic activity of platelet-derived and basic fibroblast growth factors in human vascular smooth muscle cells.

Authors:  Teresa Padró; Rolf M Mesters; Berno Dankbar; Heike Hintelmann; Ralf Bieker; Michael Kiehl; Wolfgang E Berdel; Joachim Kienast
Journal:  J Cell Sci       Date:  2002-05-01       Impact factor: 5.285
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  1 in total

1.  Supra-additive expression of interleukin-6, interleukin-8 and basic fibroblast growth factor in vascular smooth muscle cells following coinfection with Chlamydia pneumoniae and cytomegalovirus as a novel link between infection and atherosclerosis.

Authors:  Dirk Prochnau; Eberhard Straube; Hans-Reiner Figulla; Jürgen Rödel
Journal:  Can J Infect Dis Med Microbiol       Date:  2012       Impact factor: 2.471
  1 in total

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