Literature DB >> 15270696

Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?

J P Chapple1, J van der Spuy, S Poopalasundaram, M E Cheetham.   

Abstract

The heat-shock protein 70 chaperone machine is functionally connected to the ubiquitin-proteasome system by the co-chaperone CHIP. In this article, we discuss evidence that the neuronal DnaJ proteins HSJ1a and HSJ1b may represent a further link between the cellular protein folding and degradation machineries. We have demonstrated that HSJ1 proteins contain putative ubiquitin interaction motifs and can modulate the cellular processing of rhodopsin, a protein that is targeted for degradation by the proteasome when it is misfolded.

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Year:  2004        PMID： 15270696     DOI： 10.1042/BST0320640

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  11 in total

1.  DNAJB2 expression in normal and diseased human and mouse skeletal muscle.

Authors:  Kristl G Claeys; Magdalena Sozanska; Jean-Jacques Martin; Emmanuelle Lacene; Ludivine Vignaud; Daniel Stockholm; Pascal Laforêt; Bruno Eymard; Antoine Kichler; Daniel Scherman; Thomas Voit; David Israeli
Journal:  Am J Pathol       Date:  2010-04-15       Impact factor: 4.307

2.  Functional relevance of J-protein family of rice (Oryza sativa).

Authors:  Neelam K Sarkar; Upasna Thapar; Preeti Kundnani; Priyankar Panwar; Anil Grover
Journal:  Cell Stress Chaperones       Date:  2012-11-16       Impact factor: 3.667

Review 3.  The HSP70 chaperone machinery: J proteins as drivers of functional specificity.

Authors:  Harm H Kampinga; Elizabeth A Craig
Journal:  Nat Rev Mol Cell Biol       Date:  2010-08       Impact factor: 94.444

4.  Suppression of protein aggregation by chaperone modification of high molecular weight complexes.

Authors:  John Labbadia; Sergey S Novoselov; John S Bett; Andreas Weiss; Paolo Paganetti; Gillian P Bates; Michael E Cheetham
Journal:  Brain       Date:  2012-03-06       Impact factor: 13.501

5.  Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.

Authors:  Johanna M Rose; Sergey S Novoselov; Philip A Robinson; Michael E Cheetham
Journal:  Hum Mol Genet       Date:  2010-10-01       Impact factor: 6.150

Review 6.  Barcoding heat shock proteins to human diseases: looking beyond the heat shock response.

Authors:  Vaishali Kakkar; Melanie Meister-Broekema; Melania Minoia; Serena Carra; Harm H Kampinga
Journal:  Dis Model Mech       Date:  2014-04       Impact factor: 5.758

Review 7.  The E3 ligase CHIP: insights into its structure and regulation.

Authors:  Indranil Paul; Mrinal K Ghosh
Journal:  Biomed Res Int       Date:  2014-04-24       Impact factor: 3.411

8.  Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.

Authors:  Jin Zhang; Ke Wang; Yan Guo; Qi Shi; Chan Tian; Cao Chen; Chen Gao; Bao-Yun Zhang; Xiao-Ping Dong
Journal:  Virol J       Date:  2012-12-06       Impact factor: 4.099

Review 9.  Molecular cochaperones: tumor growth and cancer treatment.

Authors:  Stuart K Calderwood
Journal:  Scientifica (Cairo)       Date:  2013-04-17

Review 10.  J protein mutations and resulting proteostasis collapse.

Authors:  Carolina Koutras; Janice E A Braun
Journal:  Front Cell Neurosci       Date:  2014-07-08       Impact factor: 5.505
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